PMID- 18841157
OWN - NLM
STAT- MEDLINE
DCOM- 20081124
LR  - 20181113
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Print)
IS  - 0007-0920 (Linking)
VI  - 99
IP  - 9
DP  - 2008 Nov 4
TI  - Downregulation of HLA Class I molecules in the tumour is associated with a poor 
      prognosis in patients with oesophageal squamous cell carcinoma.
PG  - 1462-7
LID - 10.1038/sj.bjc.6604715 [doi]
AB  - As antigenic peptides in the context of human leukocyte antigen (HLA) class I 
      molecules are recognised by cytotoxic T lymphocytes (CTL), the downregulation of 
      HLA class I molecules is one of the reasons why tumour cells can evade 
      CTL-mediated anti-tumour immunity. In this study, we investigated HLA class I 
      expression in oesophageal squamous cell carcinoma (ESCC) (n=70) and in their 
      metastatic lesions (lymph nodes (n=40) and liver (n=3)), by immunohistochemistry 
      with anti-HLA class I monoclonal antibody (EMR8-5). As a result, the 
      downregulation of HLA class I expression in primary lesions of ESCC was observed 
      in 43%, and that in metastatic lymph nodes was noted in 90%. Furthermore, 
      patients with preserved HLA class I expression in primary tumours showed a better 
      survival in comparison to those with downregulated HLA class I molecules 
      (P<0.01). Furthermore, multivariate analysis using Cox's proportional hazards 
      model revealed that the downregulated expression of HLA class I in primary 
      lesions was an independent, unfavourable prognostic factor (P<0.01). In 
      conclusion, the downregulation of HLA class I expression frequently occurred in 
      primary tumour and, to a greater extent, in metastatic lesions of patients with 
      ESCC and was associated with patient survival.
FAU - Mizukami, Y
AU  - Mizukami Y
AD  - First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo-city, 
      Yamanashi 409-3898, Japan.
FAU - Kono, K
AU  - Kono K
FAU - Maruyama, T
AU  - Maruyama T
FAU - Watanabe, M
AU  - Watanabe M
FAU - Kawaguchi, Y
AU  - Kawaguchi Y
FAU - Kamimura, K
AU  - Kamimura K
FAU - Fujii, H
AU  - Fujii H
LA  - eng
PT  - Journal Article
DEP - 20081007
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*immunology/mortality/pathology
MH  - Down-Regulation
MH  - Esophageal Neoplasms/*immunology/mortality/pathology
MH  - Female
MH  - Histocompatibility Antigens Class I/*analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
PMC - PMC2579690
EDAT- 2008/10/09 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/11/04
CRDT- 2008/10/09 09:00
PHST- 2008/10/09 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/10/09 09:00 [entrez]
PHST- 2009/11/04 00:00 [pmc-release]
AID - 6604715 [pii]
AID - 10.1038/sj.bjc.6604715 [doi]
PST - ppublish
SO  - Br J Cancer. 2008 Nov 4;99(9):1462-7. doi: 10.1038/sj.bjc.6604715. Epub 2008 Oct 
      7.