PMID- 18841308
OWN - NLM
STAT- MEDLINE
DCOM- 20081216
LR  - 20081008
IS  - 1525-7886 (Print)
IS  - 1525-7886 (Linking)
VI  - 59
IP  - 5
DP  - 2008 Sep-Oct
TI  - Simultaneous determination of heavy metals in cosmetic products.
PG  - 441-8
AB  - An extremely small amount of several heavy metals have been detected in cosmetic 
      products as impurities, which can cause skin allergies through percutaneous 
      adsorption on the skin. We present here a fast, accurate, and highly sensitive 
      method for simultaneous determination of Pb2+, Fe2+, Cu2+, Ni2+, Zn2+, Co2+, Cd2+ 
      and Mn2+ in coloring agents and cosmetic products, to be evaluated by ion 
      chromatography. All of these metals are well separated through a bifunctional 
      ion-exchange column (IonPac CS5A) and detected by post-column reaction and 
      spectrophotometric detection. The calibration graphs are linear (r2 > 0.999), in 
      the range 0.1-1000 microg/ml. Detection limits for a 200-microl sample solution 
      are at the mug/l level, which is sufficient for judging whether the product is 
      safe or not. The relative standard deviations (RSDs) of the retention time and 
      the peak area are less than 0.21% and 1.24%, respectively. The recovery rates are 
      97-104%. The result shows that the proposed determination method is more 
      sensitive, more accurate, and faster than current methods such as HPLC, ICP-MS 
      and Flame-AAS. The new method was applied to analyze the amount of heavy metals 
      contained in 22 cosmetic products and 11 coloring agents.
FAU - Lee, So-Mi
AU  - Lee SM
AD  - Amore Pacific Corporation, 314-1 Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-do, 
      446-729, Republic of Korea.
FAU - Jeong, Hye-Jin
AU  - Jeong HJ
FAU - Chang, Ih Seop
AU  - Chang IS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cosmet Sci
JT  - Journal of cosmetic science
JID - 9814276
RN  - 0 (Cosmetics)
RN  - 0 (Metals, Heavy)
SB  - IM
MH  - Cosmetics/*chemistry
MH  - Metals, Heavy/*analysis
EDAT- 2008/10/09 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/10/09 09:00
PHST- 2008/04/09 00:00 [accepted]
PHST- 2008/10/09 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/10/09 09:00 [entrez]
PST - ppublish
SO  - J Cosmet Sci. 2008 Sep-Oct;59(5):441-8.