PMID- 18841479
OWN - NLM
STAT- MEDLINE
DCOM- 20090406
LR  - 20181113
IS  - 1530-9932 (Electronic)
IS  - 1530-9932 (Linking)
VI  - 9
IP  - 4
DP  - 2008
TI  - Prediction of tablet film-coating thickness using a rotating plate coating system 
      and NIR spectroscopy.
PG  - 1047-53
LID - 10.1208/s12249-008-9142-9 [doi]
AB  - The purpose of this research was to create a calibration model based on 
      near-infrared (NIR) spectroscopy data obtained during a small-scale coating 
      process to predict in-line the coating layer thickness of tablets coated in a 
      side-vented drum coater. The developed setup for the small-scale coating process 
      consisted of a rotating plate with 20 tablets molds that pass a spraying unit, a 
      heating unit, and an in-line NIR spectroscopy probe during one rotation. 
      High-density polyethylene (HDPE) was compressed to flat-faced tablets, and these 
      were coated with a sustained release coating suspension containing Kollicoat IR 
      and Kollicoat SR 30D. The film thickness of these tablets was determined for each 
      tablet individually with a digital micrometer. A calibration model of predicted 
      film thickness versus real-film thickness using PLS regression was developed. 
      This model was tested against in-line NIR data obtained from a coating drum 
      process, in which biconvex HDPE tablets were film-coated with the same 
      film-coating suspension. The model predicted a final coating thickness of 240 
      mum, while the measured average thickness (n = 100 tablets) was 210 mum. Taking 
      into account the use of a different setup and differently shaped tablets, it was 
      possible to predict the coating thickness with accuracy comparable to the one of 
      the digital micrometer. Thus, the small-scale rotating plate system was found to 
      be an efficient means of preparing calibration model for a tablet-coating drum 
      process.
FAU - Romer, Meike
AU  - Romer M
AD  - Division of Pharmaceutical Technology, Faculty of Pharmacy, University of 
      Helsinki, P.O. Box 56, Helsinki 00014, Finland. meike.romer@helsinki.fi
FAU - Heinamaki, Jyrki
AU  - Heinamaki J
FAU - Strachan, Clare
AU  - Strachan C
FAU - Sandler, Niklas
AU  - Sandler N
FAU - Yliruusi, Jouko
AU  - Yliruusi J
LA  - eng
PT  - Journal Article
DEP - 20081008
PL  - United States
TA  - AAPS PharmSciTech
JT  - AAPS PharmSciTech
JID - 100960111
RN  - 0 (Tablets)
SB  - IM
MH  - Chemistry, Pharmaceutical
MH  - Multivariate Analysis
MH  - Spectroscopy, Near-Infrared/*methods
MH  - *Tablets
PMC - PMC2628279
EDAT- 2008/10/09 09:00
MHDA- 2009/04/07 09:00
PMCR- 2009/10/08
CRDT- 2008/10/09 09:00
PHST- 2008/03/06 00:00 [received]
PHST- 2008/08/20 00:00 [accepted]
PHST- 2008/10/09 09:00 [pubmed]
PHST- 2009/04/07 09:00 [medline]
PHST- 2008/10/09 09:00 [entrez]
PHST- 2009/10/08 00:00 [pmc-release]
AID - 9142 [pii]
AID - 10.1208/s12249-008-9142-9 [doi]
PST - ppublish
SO  - AAPS PharmSciTech. 2008;9(4):1047-53. doi: 10.1208/s12249-008-9142-9. Epub 2008 
      Oct 8.