PMID- 18841571
OWN - NLM
STAT- MEDLINE
DCOM- 20090325
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 25
IP  - 5
DP  - 2008 Oct
TI  - [Absence of association of the L296Q polymorphism in the cholesteryl ester 
      transfer protein gene with type 2 diabetes mellitus in Chinese].
PG  - 555-9
AB  - OBJECTIVE: To investigate the association between L296Q polymorphism in the 
      cholesterol ester transfer protein(CETP)gene and type 2 diabetes 
      mellitus(T2DM)and blood lipids. METHODS: Plasma glucose and lipid levels were 
      measured in a total of 303 subjects recruited from the West China Hospital of 
      Sichuan University. The subjects were divided into 4 groups according to the 
      levels of plasma glucose and triglyceride, namely T2DM with hypertriglyceridemia 
      group, group of T2DM with normal triglyceride, group of hypertriglyceridemia 
      without DM and group of normal controls, respectively. Genotypes of L296Q 
      polymorphism in the CETP gene of all subjects were analyzed by real-time 
      fluorescent quantitative PCR(FQ-PCR). RESULTS: No significant differences were 
      observed in the frequencies of genotypes LL and LQ and the 296Q allele among the 
      four groups (chi-square=3.459, P>0.05; chi-square=3.155, P>0.05, respectively), 
      nor the frequencies of genotypes LL and LQ between the T2DM and non-T2DM, or 
      plasma lipid levels between the 296Q allele carriers and those of genotype LL. 
      CONCLUSION: No association was found between the L296Q polymorphism in the CETP 
      gene and T2DM as well as plasma lipid levels in various groups of Chinese in this 
      study.
FAU - Gao, Yun
AU  - Gao Y
AD  - Department of Endocrinology, the West China Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, P.R. China.
FAU - Zhu, Lin
AU  - Zhu L
FAU - Long, Yang
AU  - Long Y
FAU - Ren, Yan
AU  - Ren Y
FAU - Chen, Tao
AU  - Chen T
FAU - Zhang, Xiangxun
AU  - Zhang X
FAU - Tian, Haoming
AU  - Tian H
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Cholesterol Ester Transfer Proteins)
RN  - 0 (Lipids)
SB  - IM
MH  - Asian People/*genetics
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Cholesterol Ester Transfer Proteins/*genetics
MH  - Diabetes Mellitus, Type 2/blood/*genetics/pathology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Sequence Analysis, DNA
EDAT- 2008/10/09 09:00
MHDA- 2009/03/26 09:00
CRDT- 2008/10/09 09:00
PHST- 2008/10/09 09:00 [pubmed]
PHST- 2009/03/26 09:00 [medline]
PHST- 2008/10/09 09:00 [entrez]
AID - 940625121 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008 Oct;25(5):555-9.