PMID- 18842265
OWN - NLM
STAT- MEDLINE
DCOM- 20090805
LR  - 20151119
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 204
IP  - 1
DP  - 2009 May
TI  - Chemotaxis analysis of circulating monocytes in patients with a recent acute 
      coronary syndrome.
PG  - 304-8
LID - 10.1016/j.atherosclerosis.2008.08.015 [doi]
AB  - BACKGROUND: Monocytes/macrophages are crucially involved in the process of 
      atherogenesis. Presence of an acute coronary syndrome (ACS) is associated with 
      macrophage activation. We investigated whether ligand-induced monocyte chemotaxis 
      can serve as biomarker in recent ACS and discriminate ACS from stable coronary 
      artery disease (CAD). METHODS: In a prospective study, the migratory response of 
      monocytes towards the chemotactic ligands vascular endothelial growth factor-A 
      (VEGF-A) and monocyte chemoattractant protein-1 (MCP-1) in patients with recent 
      ACS (n=29) (median time period since cardiovascular event, 11 days) and stable 
      CAD patients (n=41) was analysed. Furthermore, blood levels of C-reactive protein 
      (CRP), VEGF-A and soluble vascular endothelial growth factor receptor-1 
      (sVEGRF-1) were determined. RESULTS: Unexpectedly, VEGF-A-induced monocyte 
      chemotaxis did not differ between ACS and CAD. The same was true for the 
      chemotactic response of monocytes towards MCP-1. In addition, we could not find 
      any difference in VEGF-A and sVEGFR-1 levels between recent ACS and stable CAD. 
      CRP was significantly enhanced in the ACS group, but did not correlate with the 
      VEGF-A- and MCP-1-induced chemotaxis. CONCLUSIONS: Recent ACS is not associated 
      with enhanced monocyte chemotaxis towards VEGF-A and MCP-1. Therefore, VEGF-A- 
      and MCP-1-induced monocyte chemotaxis as a potential novel biomarker remains 
      unaffected by recent ACS.
FAU - Czepluch, Frauke S
AU  - Czepluch FS
AD  - Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), 
      University of Maastricht, Maastricht, The Netherlands.
FAU - Zweigle, Bernhard
AU  - Zweigle B
FAU - Waltenberger, Johannes
AU  - Waltenberger J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080826
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 2.7.10.1 (FLT1 protein, human)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
SB  - IM
MH  - Acute Coronary Syndrome/*blood
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Cell Migration Assays, Leukocyte
MH  - Cells, Cultured
MH  - Chemokine CCL2/metabolism
MH  - *Chemotaxis, Leukocyte
MH  - Coronary Artery Disease/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - Prospective Studies
MH  - Vascular Endothelial Growth Factor A/blood
MH  - Vascular Endothelial Growth Factor Receptor-1/blood
EDAT- 2008/10/10 09:00
MHDA- 2009/08/06 09:00
CRDT- 2008/10/10 09:00
PHST- 2008/05/21 00:00 [received]
PHST- 2008/08/13 00:00 [revised]
PHST- 2008/08/13 00:00 [accepted]
PHST- 2008/10/10 09:00 [pubmed]
PHST- 2009/08/06 09:00 [medline]
PHST- 2008/10/10 09:00 [entrez]
AID - S0021-9150(08)00593-5 [pii]
AID - 10.1016/j.atherosclerosis.2008.08.015 [doi]
PST - ppublish
SO  - Atherosclerosis. 2009 May;204(1):304-8. doi: 
      10.1016/j.atherosclerosis.2008.08.015. Epub 2008 Aug 26.