PMID- 18843279
OWN - NLM
STAT- MEDLINE
DCOM- 20090811
LR  - 20220223
IS  - 1476-5527 (Electronic)
IS  - 0950-9240 (Linking)
VI  - 23
IP  - 4
DP  - 2009 Apr
TI  - Association between serum concentrations of persistent organic pollutants and 
      prevalence of newly diagnosed hypertension: results from the National Health and 
      Nutrition Examination Survey 1999-2002.
PG  - 274-86
LID - 10.1038/jhh.2008.124 [doi]
AB  - Epidemiological studies have suggested a link between exposure to persistent 
      organic pollutants (POPs) and hypertension. Cross-sectional associations of serum 
      POP concentrations with the prevalence of newly diagnosed hypertension were 
      investigated in 524 adult participants aged >/=40 years in the National Health 
      and Nutrition Examination Survey 1999-2002. Twenty-one POPs (three 
      polychlorinated dibenzo-p-dioxins (PCDDs), three polychlorinated dibenzofurans 
      (PCDFs), five dioxin-like polychlorinated biphenyls (PCBs), six dioxin-unlike 
      PCBs and four organochlorine (OC) pesticides) were selected because they were 
      detectable in > or =60% of participants. Serum concentrations of PCDDs and PCDFs 
      were associated with prevalent but newly diagnosed hypertension among women, but 
      not among men. Across quartiles of the sum of category numbers of the three PCDDs 
      and the three PCDFs, adjusted odds ratios in women were 1.0, 4.2 (95% confidence 
      interval (CI): 1.0-17.1), 4.5 (1.0-19.9) and 5.0 (1.2-21.5) (P for trend=0.08) 
      and 1.0, 2.6 (0.8-9.0), 5.9 (1.7-20.0) and 4.2 (1.3-14.3) (P for trend=0.01), 
      respectively. On the other hand, PCBs tended toward positive association with 
      hypertension only among men. Adjusted odds ratios in men in the highest quartiles 
      of the sum of category numbers of the dioxin-like and non-dioxin-like PCBs were 
      2.3 (0.8-6.6) and 2.8 (0.9-8.5) (P for trend=0.11 or 0.04), respectively. OC 
      pesticides were not clearly associated with hypertension in either gender. 
      Hypertension had gender-specific associations with serum concentrations of some 
      POPs. Considering the common presence of exposure to POPs in the general 
      population, these findings need to be clarified in prospective studies.
FAU - Ha, M-H
AU  - Ha MH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, 101 Dongin-dong, Jung-gu, Daegu, Korea.
FAU - Lee, D-H
AU  - Lee DH
FAU - Son, H-K
AU  - Son HK
FAU - Park, S-K
AU  - Park SK
FAU - Jacobs, D R Jr
AU  - Jacobs DR Jr
LA  - eng
PT  - Journal Article
DEP - 20081009
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hypertension/*blood/*epidemiology
MH  - Male
MH  - Nutrition Surveys
MH  - Prevalence
MH  - United States
EDAT- 2008/10/10 09:00
MHDA- 2009/08/12 09:00
CRDT- 2008/10/10 09:00
PHST- 2008/10/10 09:00 [pubmed]
PHST- 2009/08/12 09:00 [medline]
PHST- 2008/10/10 09:00 [entrez]
AID - jhh2008124 [pii]
AID - 10.1038/jhh.2008.124 [doi]
PST - ppublish
SO  - J Hum Hypertens. 2009 Apr;23(4):274-86. doi: 10.1038/jhh.2008.124. Epub 2008 Oct 
      9.