PMID- 18844260
OWN - NLM
STAT- MEDLINE
DCOM- 20090205
LR  - 20111117
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 23
IP  - 2
DP  - 2009 Feb
TI  - Antioxidant properties and xanthine oxidase inhibitory effects of Tamus communis 
      L. root extracts.
PG  - 283-8
LID - 10.1002/ptr.2621 [doi]
AB  - This study was conducted to search for xanthine oxidase (XO) inhibitors from the 
      root extracts of Tamus communis L. traditionally used in folk medicine in 
      Algeria. Root extracts with different solvents were screened for purified milk 
      xanthine oxidase inhibition. The root extracts (methanol, chloroform and ethyl 
      acetate) and proteins, obtained in distilled water, inhibited bovine, sheep and 
      human milk XO from three species in a concentration-dependent manner, with an 
      additional superoxide scavenging capacity, which reached its highest level with 
      ethyl acetate extract (IC(50) = 0.15, 0.04 and 0.09 g/L) for bovine XO, sheep XO 
      and human XO, respectively. The antioxidant potential was confirmed with the 
      non-enzymatic method, total radical-trapping antioxidant parameter (TRAP) assay, 
      which showed that the Tamus communis L. extracts have a potential antioxidant 
      activity in the same order obtained by using the reduction of cytochrome c, an 
      enzymatic method, in which the antioxidant activity followed a decreasing order: 
      ethyl acetate extract > chloroform extract > protein.
CI  - Copyright (c) 2008 John Wiley & Sons, Ltd.
FAU - Boumerfeg, Sabah
AU  - Boumerfeg S
AD  - Laboratory of Applied Biochemistry, Department of Biology, Faculty of Sciences, 
      University Ferhat Abbas of Setif 19000, Algeria.
FAU - Baghiani, Abderrahmane
AU  - Baghiani A
FAU - Messaoudi, Dalila
AU  - Messaoudi D
FAU - Khennouf, Seddik
AU  - Khennouf S
FAU - Arrar, Lekhmici
AU  - Arrar L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Phenols)
RN  - 0 (Plant Extracts)
RN  - 0 (Polyphenols)
RN  - EC 1.17.3.2 (Xanthine Oxidase)
SB  - IM
MH  - Algeria
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Cattle
MH  - Dose-Response Relationship, Drug
MH  - Flavonoids/isolation & purification
MH  - Free Radical Scavengers/pharmacology
MH  - Humans
MH  - Medicine, Traditional
MH  - Milk/enzymology
MH  - Phenols/isolation & purification
MH  - Plant Extracts/*pharmacology
MH  - Plant Roots/chemistry
MH  - Polyphenols
MH  - Sheep
MH  - Tamus/*chemistry
MH  - Xanthine Oxidase/*antagonists & inhibitors
EDAT- 2008/10/11 09:00
MHDA- 2009/02/06 09:00
CRDT- 2008/10/11 09:00
PHST- 2008/10/11 09:00 [pubmed]
PHST- 2009/02/06 09:00 [medline]
PHST- 2008/10/11 09:00 [entrez]
AID - 10.1002/ptr.2621 [doi]
PST - ppublish
SO  - Phytother Res. 2009 Feb;23(2):283-8. doi: 10.1002/ptr.2621.