PMID- 18844590
OWN - NLM
STAT- MEDLINE
DCOM- 20081106
LR  - 20091119
IS  - 1744-8395 (Electronic)
IS  - 1476-0584 (Linking)
VI  - 7
IP  - 8
DP  - 2008 Oct
TI  - Specific Lactobacillus species differentially activate Toll-like receptors and 
      downstream signals in dendritic cells.
PG  - 1155-64
LID - 10.1586/14760584.7.8.1155 [doi]
AB  - BACKGROUND: Dendritic cells (DCs) regulate mucosal T-cell immunity and encounter 
      several distinct bacteria of the gut flora, including lactobacilli. Gram-positive 
      lactobacilli have been suggested to play an important role in exerting 
      adjuvanticity effects on innate immune cells at mucosal sites. AIMS & METHODS: In 
      the present report, we studied the effects of specific Lactobacillus species on 
      human monocyte derived DCs. RESULTS: We show that lactobacilli activate DCs by 
      differentially inducing the expression of Toll-like receptors and bioactive IL-12 
      in Lactobacillus-treated DCs. Further, these specific Lactobacillus spp. did not 
      activate the phosphorylation of p38 MAPK, which might be a downstream effect of 
      the remarkable capacity of lactobacilli to induce IL-12 in DCs that skew T cells 
      significantly toward an IFN-gamma-secreting Th1 response. CONCLUSION: These 
      results highlight an important role of specific Lactobacillus spp. as adjuvants 
      in triggering DC function, which in turn may determine the immunological outcome 
      in an environment wherein innate cells reside.
FAU - Mohamadzadeh, Mansour
AU  - Mohamadzadeh M
AD  - Johns Hopkins University School of Medicine, The Sidney Kimmel Comprehensive 
      Cancer Center, 209 David H Koch Cancer Research Building, 1550 Orleans Street, 
      Baltimore, MD 21231, USA. mmohama2@jhmi.edu
FAU - Klaenhammer, Todd R
AU  - Klaenhammer TR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Expert Rev Vaccines
JT  - Expert review of vaccines
JID - 101155475
RN  - 0 (Toll-Like Receptors)
RN  - 187348-17-0 (Interleukin-12)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Gene Expression Profiling
MH  - Humans
MH  - Interleukin-12/biosynthesis
MH  - Lactobacillus/*immunology
MH  - Phosphorylation
MH  - Toll-Like Receptors/*biosynthesis
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
EDAT- 2008/10/11 09:00
MHDA- 2008/11/07 09:00
CRDT- 2008/10/11 09:00
PHST- 2008/10/11 09:00 [pubmed]
PHST- 2008/11/07 09:00 [medline]
PHST- 2008/10/11 09:00 [entrez]
AID - 10.1586/14760584.7.8.1155 [doi]
PST - ppublish
SO  - Expert Rev Vaccines. 2008 Oct;7(8):1155-64. doi: 10.1586/14760584.7.8.1155.