PMID- 18845332
OWN - NLM
STAT- MEDLINE
DCOM- 20090122
LR  - 20090514
IS  - 0141-1136 (Print)
IS  - 0141-1136 (Linking)
VI  - 66
IP  - 5
DP  - 2008 Dec
TI  - Semipermeable membrane devices link site-specific contaminants to effects: PART 
      II - A comparison of lingering Exxon Valdez oil with other potential sources of 
      CYP1A inducers in Prince William Sound, Alaska.
PG  - 487-98
LID - 10.1016/j.marenvres.2008.08.007 [doi]
AB  - We deployed semipermeable membrane devices (SPMDs) on beaches for 28 days at 53 
      sites in Prince William Sound (PWS), Alaska, to evaluate the induction potential 
      from suspected sources of cytochrome P450 1A (CYP1A)-inducing contaminants. Sites 
      were selected to assess known point sources, or were chosen randomly to evaluate 
      the region-wide sources. After deployment, SPMD extracts were analyzed chemically 
      for persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons 
      (PAH). These results were compared with hepatic CYP1A enzyme activity of juvenile 
      rainbow trout injected with the same extracts prior to clean-up for the chemical 
      analyses. Increased CYP1A activity was strongly associated with PAH 
      concentrations in extracts, especially chrysene homologues but was not associated 
      with POPs. The only apparent sources of chrysene homologues were lingering oil 
      from Exxon Valdez, asphalt and bunker fuels released from storage tanks during 
      the 1964 Alaska earthquake, creosote leaching from numerous pilings at one site, 
      and PAH-contaminated sediments at Cordova Harbor. Our results indicate that PWS 
      is remarkably free of pollution from PAH when nearby sources are absent as well 
      as from pesticides and PCBs generally.
FAU - Short, Jeffrey W
AU  - Short JW
AD  - Alaska Fisheries Science Center, National Marine Fisheries Service, NOAA, 17109 
      Point Lena Loop Road, Juneau, AK 99801, USA. Jeff.Short@noaa.gov
FAU - Springman, Kathrine R
AU  - Springman KR
FAU - Lindeberg, Mandy R
AU  - Lindeberg MR
FAU - Holland, Larry G
AU  - Holland LG
FAU - Larsen, Marie L
AU  - Larsen ML
FAU - Sloan, Catherine A
AU  - Sloan CA
FAU - Khan, Colin
AU  - Khan C
FAU - Hodson, Peter V
AU  - Hodson PV
FAU - Rice, Stanley D
AU  - Rice SD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080826
PL  - England
TA  - Mar Environ Res
JT  - Marine environmental research
JID - 9882895
RN  - 0 (Petroleum)
RN  - 0 (Water Pollutants, Chemical)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
CIN - Mar Environ Res. 2009 May-Jun;67(4-5):262-7; author reply 259-61. PMID: 19349074
MH  - Alaska
MH  - Animals
MH  - Biological Availability
MH  - Cytochrome P-450 CYP1A1/*metabolism
MH  - Environmental Monitoring/*instrumentation/*methods
MH  - Enzyme Induction/drug effects
MH  - Oncorhynchus mykiss/metabolism
MH  - *Petroleum
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2008/10/11 09:00
MHDA- 2009/01/23 09:00
CRDT- 2008/10/11 09:00
PHST- 2008/03/28 00:00 [received]
PHST- 2008/08/18 00:00 [revised]
PHST- 2008/08/19 00:00 [accepted]
PHST- 2008/10/11 09:00 [pubmed]
PHST- 2009/01/23 09:00 [medline]
PHST- 2008/10/11 09:00 [entrez]
AID - S0141-1136(08)00202-X [pii]
AID - 10.1016/j.marenvres.2008.08.007 [doi]
PST - ppublish
SO  - Mar Environ Res. 2008 Dec;66(5):487-98. doi: 10.1016/j.marenvres.2008.08.007. 
      Epub 2008 Aug 26.