PMID- 18847385
OWN - NLM
STAT- MEDLINE
DCOM- 20090716
LR  - 20181113
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Print)
IS  - 1540-4196 (Linking)
VI  - 7
IP  - 2
DP  - 2009 Apr
TI  - Cardiovascular disease risk factors in youth with type 1 and type 2 diabetes: 
      implications of a factor analysis of clustering.
PG  - 89-95
LID - 10.1089/met.2008.0046 [doi]
AB  - BACKGROUND: The extent to which cardiovascular disease (CVD) risk factors cluster 
      in youth with a diagnosis of type 1 (T1DM) or type 2 diabetes mellitus (T2DM) is 
      unclear. Therefore, we aimed to evaluate potential clustering of traditional CVD 
      risk factors that may reflect an unmeasured but unifying single pathology that 
      may explain the phenomenon of the metabolic syndrome in these youths. METHODS: 
      Youths who participated in the SEARCH for Diabetes in Youth study with diabetes 
      diagnosed <20 years, with current age >10 years (maximum current age, 22 years) 
      were included. Confirmatory factor analysis (CFA) was performed to determine 
      statistical associations among CVD risk factors, including obesity, blood 
      pressure, triglycerides, and high-density lipoprotein cholesterol (HDL-C). 
      Diabetes type was defined by diabetes autoantibodies (DAA) and fasting C-peptide 
      (FCP); type 1 (T1DM, DAA positive, and FCP <0.8 ng/mL, n = 1198) and type 2 
      (T2DM, DAA negative, and FCP >2.9 ng/mL, n = 95). For T1DM, the sample was split 
      randomly and analyses were conducted separately in each split sample. RESULTS: 
      Among five prespecified data structures ranging from a single underlying factor 
      to a hierarchical structure of factors, the worst-fitting model for both of the 
      T1DM split samples was the single-factor structure and the best-fitting model was 
      a three-correlated-factor structure. The three correlated factors identified were 
      obesity, lipids, and blood pressure. Results were very similar for youths with 
      T2DM. CONCLUSION: There is little evidence that a single factor underlies the CVD 
      risk factor pattern in youths with diabetes. The concept of the metabolic 
      syndrome provides a useful description of clinical characteristics but does not 
      efficiently capture a single target for etiologic research among youths with 
      diabetes.
FAU - Mayer-Davis, Elizabeth J
AU  - Mayer-Davis EJ
AD  - Department of Nutrition, University of North Carolina School of Public Health, 
      Chapel Hill, North Carolina, USA.
FAU - Ma, Bo
AU  - Ma B
FAU - Lawson, Andrew
AU  - Lawson A
FAU - D'Agostino, Ralph B Jr
AU  - D'Agostino RB Jr
FAU - Liese, Angela D
AU  - Liese AD
FAU - Bell, Ronny A
AU  - Bell RA
FAU - Dabelea, Dana
AU  - Dabelea D
FAU - Dolan, Lawrence
AU  - Dolan L
FAU - Pettitt, David J
AU  - Pettitt DJ
FAU - Rodriguez, Beatriz L
AU  - Rodriguez BL
FAU - Williams, Desmond
AU  - Williams D
CN  - SEARCH for Diabetes in Youth Study Group
LA  - eng
GR  - U01 DP000244/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP000250/DP/NCCDPHP CDC HHS/United States
GR  - DP-05-069/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP000248/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP000246/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP000254/DP/NCCDPHP CDC HHS/United States
GR  - 00097/PHS HHS/United States
GR  - U01 DP000245/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP000247/DP/NCCDPHP CDC HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (Lipids)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Blood Pressure
MH  - Cardiovascular Diseases/blood/*etiology/physiopathology
MH  - Child
MH  - Cluster Analysis
MH  - Diabetes Mellitus, Type 1/blood/*complications/physiopathology
MH  - Diabetes Mellitus, Type 2/blood/*complications/physiopathology
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Metabolic Syndrome/blood/*complications/physiopathology
MH  - Models, Biological
MH  - Obesity/complications
MH  - Risk Assessment
MH  - Risk Factors
MH  - United States
MH  - Young Adult
PMC - PMC3135884
EDAT- 2008/10/14 09:00
MHDA- 2009/07/17 09:00
PMCR- 2010/04/01
CRDT- 2008/10/14 09:00
PHST- 2008/10/14 09:00 [pubmed]
PHST- 2009/07/17 09:00 [medline]
PHST- 2008/10/14 09:00 [entrez]
PHST- 2010/04/01 00:00 [pmc-release]
AID - 10.1089/met.2008.0046 [pii]
AID - 10.1089/met.2008.0046 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2009 Apr;7(2):89-95. doi: 10.1089/met.2008.0046.