PMID- 18848781
OWN - NLM
STAT- MEDLINE
DCOM- 20090114
LR  - 20211203
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 44
IP  - 2
DP  - 2008 Nov
TI  - A genetic contribution to circulating cytokines and obesity in children.
PG  - 242-7
LID - 10.1016/j.cyto.2008.08.006 [doi]
AB  - Cytokines are considered to be involved in obesity-related metabolic diseases. 
      Study objectives are to determine the heritability of circulating cytokine 
      levels, to investigate pleiotropy between cytokines and obesity traits, and to 
      present genome scan results for cytokines in 1030 Hispanic children enrolled in 
      VIVA LA FAMILIA Study. Cytokine phenotypes included monocyte chemoattractant 
      protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), leptin, adiponectin, 
      soluble intercellular adhesion molecule-1 (sICAM-1), transforming growth factor 
      beta 1 (TGF-beta1), C-reactive protein (CRP), regulated upon activation, normal 
      T-cell expressed and secreted (RANTES) and eotaxin. Obesity-related phenotypes 
      included body mass index (BMI), fat mass (FM), truncal FM and fasting serum 
      insulin. Heritabilities ranged from 0.33 to 0.97. Pleiotropy was observed between 
      cytokines and obesity traits. Positive genetic correlations were seen between 
      CRP, leptin, MCP-1 and obesity traits, and negative genetic correlations with 
      adiponectin, ICAM-1 and TGF-beta1. Genome-wide scan of sICAM-1 mapped to 
      chromosome 3 (LOD=3.74) between markers D3S1580 and D3S1601, which flanks the 
      adiponectin gene (ADIPOQ). Suggestive linkage signals were found in other 
      chromosomal regions for other cytokines. In summary, significant heritabilities 
      for circulating cytokines, pleiotropy between cytokines and obesity traits, and 
      linkage for sICAM-1 on chromosome 3q substantiate a genetic contribution to 
      circulating cytokine levels in Hispanic children.
FAU - Cai, Guowen
AU  - Cai G
AD  - USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 
      Bates Street, Houston, TX 77030, USA.
FAU - Cole, Shelley A
AU  - Cole SA
FAU - Butte, Nancy F
AU  - Butte NF
FAU - Smith, C Wayne
AU  - Smith CW
FAU - Mehta, Nitesh R
AU  - Mehta NR
FAU - Voruganti, V Saroja
AU  - Voruganti VS
FAU - Proffitt, J Michael
AU  - Proffitt JM
FAU - Comuzzie, Anthony G
AU  - Comuzzie AG
LA  - eng
GR  - R01 DK059264/DK/NIDDK NIH HHS/United States
GR  - R01 DK059264-05/DK/NIDDK NIH HHS/United States
GR  - R01 DK59624/DK/NIDDK NIH HHS/United States
GR  - C06 RR017515/RR/NCRR NIH HHS/United States
GR  - C06 RR13556/RR/NCRR NIH HHS/United States
GR  - C06 RR013556/RR/NCRR NIH HHS/United States
GR  - R06 RR017515/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20081010
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Cytokines)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Anthropometry
MH  - Body Composition/genetics
MH  - Body Mass Index
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*blood/genetics/immunology
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Hispanic or Latino/genetics
MH  - Humans
MH  - Obesity/*blood/*genetics/immunology
MH  - Phenotype
MH  - Young Adult
PMC - PMC2644283
MID - NIHMS90468
EDAT- 2008/10/14 09:00
MHDA- 2009/01/15 09:00
PMCR- 2009/11/01
CRDT- 2008/10/14 09:00
PHST- 2008/02/14 00:00 [received]
PHST- 2008/08/07 00:00 [accepted]
PHST- 2008/10/14 09:00 [pubmed]
PHST- 2009/01/15 09:00 [medline]
PHST- 2008/10/14 09:00 [entrez]
PHST- 2009/11/01 00:00 [pmc-release]
AID - S1043-4666(08)00689-3 [pii]
AID - 10.1016/j.cyto.2008.08.006 [doi]
PST - ppublish
SO  - Cytokine. 2008 Nov;44(2):242-7. doi: 10.1016/j.cyto.2008.08.006. Epub 2008 Oct 
      10.