PMID- 18848853
OWN - NLM
STAT- MEDLINE
DCOM- 20090311
LR  - 20081208
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 69
IP  - 12
DP  - 2008 Dec
TI  - Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian 
      population from the state of Parana.
PG  - 872-6
LID - 10.1016/j.humimm.2008.09.002 [doi]
AB  - Killer cell immunoglobulin-like receptors (KIR) are encoded by polymorphic genes 
      and have as binding human leukocyte antigen (HLA) class I molecules. The aim of 
      this study was to investigate the distribution of KIR genes and inhibitory 
      KIR/HLA pairs in a population from Southern Brazil, in the state of Parana, and 
      to compare the results with results from other populations. The genotyping of 16 
      KIR genes and HLA class I alleles of 289 unrelated individuals was accomplished 
      by reverse sequence-specific oligonucleotide Luminex (One Lambda, Inc., Canoga 
      Park, CA). This Brazilian population demonstrated several similarities to 
      Caucasian populations with regard to the frequency of KIR genes. Thirty-eight 
      genotypes were defined in which the most frequent was the homozygous haplotype A 
      (33.2%). Therefore, it was possible to define two new genotypes. Most of the 
      individuals demonstrated at least one inhibitory KIR/HLA pair. Two pairs were the 
      most frequent (40.4%), followed by three pairs (38.2%), one pair (14.6%), and 
      four pairs (6.4%). The KIR2DL2/3 + HLA-C1 pair was the most frequent (79.9%) and 
      the least frequent pair was KIR3DL2 + HLA-A3/11 (25.0%). This study demonstrated 
      the diversity of KIR genes in a population of Parana, as well as the 
      characteristic pattern of Caucasians with racial admixture, which enabled the 
      definition of two new genotypes and the identification of one individual without 
      the inhibitory KIR/HLA pair.
FAU - Rudnick, Cristiane Conceicao Chagas
AU  - Rudnick CC
AD  - Laboratorio de Imunogenetica, Departamento de Analises Clinicas, Universidade 
      Estadual de Maringa, PR, Brazil.
FAU - Franceschi, Danilo Santana Alessio
AU  - Franceschi DS
FAU - Marangon, Amanda Vansan
AU  - Marangon AV
FAU - Guelsin, Glaucia Andreia Soares
AU  - Guelsin GA
FAU - Sell, Ana Maria
AU  - Sell AM
FAU - Visentainer, Jeane Eliete Laguila
AU  - Visentainer JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081009
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Brazil
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/*genetics/immunology/metabolism
MH  - Humans
MH  - Killer Cells, Natural/immunology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Protein Binding
MH  - Receptors, KIR/*genetics/immunology/metabolism
EDAT- 2008/10/14 09:00
MHDA- 2009/03/12 09:00
CRDT- 2008/10/14 09:00
PHST- 2008/05/08 00:00 [received]
PHST- 2008/08/25 00:00 [revised]
PHST- 2008/09/03 00:00 [accepted]
PHST- 2008/10/14 09:00 [pubmed]
PHST- 2009/03/12 09:00 [medline]
PHST- 2008/10/14 09:00 [entrez]
AID - S0198-8859(08)00471-0 [pii]
AID - 10.1016/j.humimm.2008.09.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2008 Dec;69(12):872-6. doi: 10.1016/j.humimm.2008.09.002. Epub 2008 
      Oct 9.