PMID- 18849489
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20210206
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 113
IP  - 2
DP  - 2009 Jan 8
TI  - Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 
      interaction.
PG  - 347-57
LID - 10.1182/blood-2008-02-137745 [doi]
AB  - By presenting antigenic peptides on the cell surface, human leukocyte antigen 
      (HLA) class I molecules are critical for immune defense. Their surface density 
      determines, to a large extent, the level of CD8(+) T cell-dependent immune 
      reactions; their loss is a major mechanism of immune escape. Therefore, powerful 
      processes should regulate their surface expression. Here we document the 
      mechanisms used by CD99 to mediate HLA class I modulation. Up-regulation of HLA 
      class I by IFN-gamma requires CD99. In the trans Golgi network (TGN), and up to 
      the cell surface, CD99 and HLA class I are physically associated via their 
      transmembrane domain. CD99 also binds p230/golgin-245, a coiled-coil protein that 
      recycles between the cytosol and buds/vesicles of the TGN and which plays a 
      fundamental role in trafficking transport vesicles. p230/golgin-245 is anchored 
      within TGN membranes via its Golgin-97, RanBP1, IMh1p, P230 (GRIP) domain and the 
      overexpression of which leads to surface and intracellular down-modulation of HLA 
      class I molecules.
FAU - Bremond, Aurore
AU  - Bremond A
AD  - Inserm UMR 576, Nice, France.
FAU - Meynet, Ophelie
AU  - Meynet O
FAU - Mahiddine, Karim
AU  - Mahiddine K
FAU - Coito, Sylvie
AU  - Coito S
FAU - Tichet, Melanie
AU  - Tichet M
FAU - Scotlandi, Katia
AU  - Scotlandi K
FAU - Breittmayer, Jean-Philippe
AU  - Breittmayer JP
FAU - Gounon, Pierre
AU  - Gounon P
FAU - Gleeson, Paul A
AU  - Gleeson PA
FAU - Bernard, Alain
AU  - Bernard A
FAU - Bernard, Ghislaine
AU  - Bernard G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081010
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (12E7 Antigen)
RN  - 0 (Antigens, CD)
RN  - 0 (Antiviral Agents)
RN  - 0 (Autoantigens)
RN  - 0 (CD99 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (GOLGA4 protein, human)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Membrane Proteins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - 12E7 Antigen
MH  - Antigens, CD/*immunology/metabolism
MH  - Antiviral Agents/immunology/pharmacology
MH  - Autoantigens/*immunology/metabolism
MH  - CD8-Positive T-Lymphocytes/*immunology/metabolism
MH  - Cell Adhesion Molecules/*immunology/metabolism
MH  - Cytosol/immunology/metabolism
MH  - Golgi Apparatus/*immunology/metabolism
MH  - HLA Antigens/biosynthesis/immunology
MH  - Histocompatibility Antigens Class I/biosynthesis/*immunology
MH  - Humans
MH  - Immunity, Cellular/physiology
MH  - Interferon-gamma/immunology/pharmacology
MH  - Jurkat Cells
MH  - Membrane Proteins/*immunology/metabolism
MH  - Protein Structure, Tertiary/physiology
MH  - Protein Transport/drug effects/immunology
MH  - Transport Vesicles/immunology/metabolism
MH  - Up-Regulation/drug effects/*immunology
EDAT- 2008/10/14 09:00
MHDA- 2009/01/28 09:00
CRDT- 2008/10/14 09:00
PHST- 2008/10/14 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
PHST- 2008/10/14 09:00 [entrez]
AID - S0006-4971(20)37883-6 [pii]
AID - 10.1182/blood-2008-02-137745 [doi]
PST - ppublish
SO  - Blood. 2009 Jan 8;113(2):347-57. doi: 10.1182/blood-2008-02-137745. Epub 2008 Oct 
      10.