PMID- 18849642
OWN - NLM
STAT- MEDLINE
DCOM- 20081217
LR  - 20081030
IS  - 1424-3911 (Electronic)
IS  - 1424-3903 (Linking)
VI  - 8
IP  - 6
DP  - 2008
TI  - Protease activation, pancreatic leakage, and inflammation in acute pancreatitis: 
      differences between mild and severe cases and changes over the first three days.
PG  - 600-7
LID - 10.1159/000161011 [doi]
AB  - BACKGROUND/AIMS: The pathophysiology of acute pancreatitis (AP) may be studied 
      using markers of protease activation (active carboxypeptidase B (aCAP), the 
      activation peptide of carboxypeptidase B (CAPAP)), leakage of pancreatic enzymes 
      (trypsinogen-2, procarboxypeptidase B (proCAP), amylase), and inflammation 
      (monocyte chemoattractant protein-1 (MCP-1), CRP). METHODS: This prospective 
      study included 140 cases of AP. Mild (n = 124) and severe (n = 16) cases were 
      compared with respect to serum levels of trypsinogen-2, proCAP, amylase, aCAP, 
      CAPAP (serum/urine), MCP-1 (serum/urine) and CRP on days 1, 2 and 3 from onset of 
      symptoms. All patients with information on all 3 days were included in a 
      time-course analysis (n = 44-55, except amylase: n = 27). RESULTS: High levels in 
      severe versus mild cases were seen for trypsinogen-2, CAPAP in serum and urine, 
      and MCP-1 in serum on days 1-3. No differences were seen for proCAP, amylase and 
      aCAP. MCP-1 in urine was significantly elevated on day 1-2, and CRP on day 2-3. 
      CAPAP and MCP-1 levels peaked early and stayed elevated for 48 h in serum. 
      CONCLUSION: Protease activation and inflammation are early events in AP, with 
      high levels of these markers within 24 h. Protease activation declines after 48 
      h, whereas inflammation is present for a longer time.
CI  - Copyright 2008 S. Karger AG, Basel and IAP.
FAU - Regner, S
AU  - Regner S
AD  - Department of Surgery, Malmo University Hospital, Lund University, Lund, Sweden. 
      sara.regner@med.lu.se
FAU - Manjer, J
AU  - Manjer J
FAU - Appelros, S
AU  - Appelros S
FAU - Hjalmarsson, C
AU  - Hjalmarsson C
FAU - Sadic, J
AU  - Sadic J
FAU - Borgstrom, A
AU  - Borgstrom A
LA  - eng
PT  - Journal Article
DEP - 20081013
PL  - Switzerland
TA  - Pancreatology
JT  - Pancreatology : official journal of the International Association of 
      Pancreatology (IAP) ... [et al.]
JID - 100966936
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 103964-84-7 (PRSS2 protein, human)
RN  - 9002-08-8 (Trypsinogen)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.2.1.- (Amylases)
RN  - EC 3.4.- (Peptide Hydrolases)
RN  - EC 3.4.17.2 (Carboxypeptidase B)
RN  - EC 3.4.21.4 (Trypsin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amylases/blood
MH  - C-Reactive Protein/metabolism
MH  - Carboxypeptidase B/blood
MH  - Chemokine CCL2/blood/urine
MH  - Enzyme Activation
MH  - Female
MH  - Humans
MH  - *Inflammation
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis/*classification/*enzymology/physiopathology
MH  - Peptide Hydrolases/*blood
MH  - Trypsin/blood
MH  - Trypsinogen/blood
EDAT- 2008/10/14 09:00
MHDA- 2008/12/18 09:00
CRDT- 2008/10/14 09:00
PHST- 2007/11/22 00:00 [received]
PHST- 2008/02/21 00:00 [accepted]
PHST- 2008/10/14 09:00 [pubmed]
PHST- 2008/12/18 09:00 [medline]
PHST- 2008/10/14 09:00 [entrez]
AID - S1424-3903(08)80092-0 [pii]
AID - 10.1159/000161011 [doi]
PST - ppublish
SO  - Pancreatology. 2008;8(6):600-7. doi: 10.1159/000161011. Epub 2008 Oct 13.