PMID- 18852666
OWN - NLM
STAT- MEDLINE
DCOM- 20081117
LR  - 20081014
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 86
IP  - 7
DP  - 2008 Oct 15
TI  - Clinical and prognostic value of discrepancies in microsatellite DNA regions 
      between recipient and donor in human leukocyte antigen-identical allogeneic 
      transplantation setting.
PG  - 983-90
LID - 10.1097/TP.0b013e318183ee2a [doi]
AB  - BACKGROUND: Detection of recipient versus donor disparities in microsatellite DNA 
      regions (short tandem repeats [STR]) allows for sensitive and specific 
      monitorization of the degree of hematopoietic chimerism. It is well known that 
      disparities between donor and recipient in various polymorphic systems (mainly 
      human leukocyte antigen [HLA]) are associated with an increased incidence of 
      graft-versus-host disease (GvHD). However, the possible biological role of STR 
      discrepancies in GvHD development has not yet been well established. METHODS: We 
      evaluated 149 consecutive patients with hematologic malignancies receiving 
      peripheral blood stem-cell transplantation from a human leukocyte 
      antigen-identical sibling donor. A total of 15 STR regions were analyzed using 
      the PowerPlex16 kit and classified as identical when recipient and donor share 
      the same alleles, and mismatched when at least one of the alleles differed. 
      RESULTS: Higher severity of acute GvHD (II-IV, P=0.043) and shorter 5-year 
      overall survival (P=0.016) was found in patients displaying more than 10 
      mismatches with respect to their donor. Additionally, higher risk of 
      transplant-related mortality (P=0.019) was found in recipient-donor pairs with 
      discrepancies in the D13S317 STR marker. CONCLUSION: The present data suggest 
      that genetic incompatibilities outside the human leukocyte antigen region between 
      donors and recipients influence the outcome of patients receiving stem-cell 
      transplantation. In addition, disparities in the neighboring D13S317 region could 
      influence transplant-related mortality.
FAU - Alcoceba, Miguel
AU  - Alcoceba M
AD  - Servicio de Hematologia, Hospital Universitario de Salamanca, Salamanca, Spain.
FAU - Balanzategui, Ana
AU  - Balanzategui A
FAU - Diez-Campelo, Maria
AU  - Diez-Campelo M
FAU - Martin-Jimenez, Patricia
AU  - Martin-Jimenez P
FAU - Sarasquete, Maria Eugenia
AU  - Sarasquete ME
FAU - Chillon, M Carmen
AU  - Chillon MC
FAU - Santamaria, Carlos
AU  - Santamaria C
FAU - Perez-Simon, Jose Antonio
AU  - Perez-Simon JA
FAU - Marin, Luis
AU  - Marin L
FAU - Caballero, M Dolores
AU  - Caballero MD
FAU - San Miguel, Jesus F
AU  - San Miguel JF
FAU - Garcia-Sanz, Ramon
AU  - Garcia-Sanz R
FAU - Gonzalez, Marcos
AU  - Gonzalez M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (DNA, Satellite)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - DNA, Satellite/*genetics
MH  - Graft vs Host Disease/epidemiology/genetics/prevention & control
MH  - HLA Antigens/*genetics
MH  - Hematologic Neoplasms/genetics/mortality/surgery
MH  - Humans
MH  - Incidence
MH  - Microsatellite Repeats/*genetics
MH  - Prognosis
MH  - Risk Assessment
MH  - Survival Analysis
MH  - Survivors
MH  - Tissue Donors
MH  - Transplantation, Homologous
MH  - Treatment Outcome
EDAT- 2008/10/15 09:00
MHDA- 2008/11/18 09:00
CRDT- 2008/10/15 09:00
PHST- 2008/10/15 09:00 [pubmed]
PHST- 2008/11/18 09:00 [medline]
PHST- 2008/10/15 09:00 [entrez]
AID - 00007890-200810150-00018 [pii]
AID - 10.1097/TP.0b013e318183ee2a [doi]
PST - ppublish
SO  - Transplantation. 2008 Oct 15;86(7):983-90. doi: 10.1097/TP.0b013e318183ee2a.