PMID- 18852733
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20090505
LR  - 20081125
IS  - 1745-8331 (Electronic)
IS  - 1745-8323 (Linking)
VI  - 4
IP  - 12
DP  - 2008 Dec
TI  - Monitoring after renal transplantation: recommendations and caveats.
PG  - 658-9
LID - 10.1038/ncpneph0968 [doi]
AB  - This commentary discusses the strengths and weaknesses of a recent study reported 
      by Kobayashi and colleagues, in which paired serum samples from 297 renal 
      transplant recipients who underwent transplantation between December 1972 and 
      September 2004 were tested for the presence of human leukocyte antigen (HLA) 
      antibody at two discrete time points following surgery (2004 and 2006). Urine 
      samples collected on the same day as the serum samples, were also measured for 
      urinary protein levels. The results of the study suggest that patients with a 
      positive change in HLA antibody status in the post-transplantation period (i.e. 
      from negative to positive) plus a positive urine protein test were at increased 
      risk of developing graft dysfunction (i.e. increased serum creatinine level). 
      Solely on the basis of these data, the authors advocate that patients should be 
      monitored annually for de novo production of HLA antibodies and for an increased 
      urinary protein level by use of simple and cost-effective approaches to assess 
      the risk of graft dysfunction or failure. While the proposal is an intriguing 
      one, this commentary identifies several issues and limitations regarding 
      post-transplantation monitoring that should be considered.
FAU - Bray, Robert A
AU  - Bray RA
AD  - Histocompatibility and Molecular Immunogenetics Laboratory, Department of 
      Pathology and Laboratory Medicine at Emory University, Atlanta, GA 30322, USA. 
      rbray@emory.edu
FAU - Gebel, Howard M
AU  - Gebel HM
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20081014
PL  - England
TA  - Nat Clin Pract Nephrol
JT  - Nature clinical practice. Nephrology
JID - 101261800
CON - Transplantation. 2008 Jun 15;85(11):1595-600. PMID: 18551065
EDAT- 2008/10/15 09:00
MHDA- 2008/10/15 09:01
CRDT- 2008/10/15 09:00
PHST- 2008/08/29 00:00 [received]
PHST- 2008/09/05 00:00 [accepted]
PHST- 2008/10/15 09:00 [pubmed]
PHST- 2008/10/15 09:01 [medline]
PHST- 2008/10/15 09:00 [entrez]
AID - ncpneph0968 [pii]
AID - 10.1038/ncpneph0968 [doi]
PST - ppublish
SO  - Nat Clin Pract Nephrol. 2008 Dec;4(12):658-9. doi: 10.1038/ncpneph0968. Epub 2008 
      Oct 14.