PMID- 18854276
OWN - NLM
STAT- MEDLINE
DCOM- 20081104
LR  - 20081015
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 130
IP  - 5
DP  - 2008 Nov
TI  - Array-based comparative genomic hybridization characterizes a deletion associated 
      with a t(15;17) in acute promyelocytic leukemia.
PG  - 818-23
LID - 10.1309/AJCPENMUI47OGKRW [doi]
AB  - The majority of de novo leukemias are characterized by well-known recurring 
      translocations or inversions. In approximately 2% to 20% of these cases, 
      deletions accompany these rearrangements. Because such deletions are undetectable 
      by G-banding, aberrant fluorescence in situ hybridization (FISH) signal patterns 
      are often the only indication of their presence. Array-based comparative genomic 
      hybridization (a-CGH) permits examination of the entire genome at a resolution 
      unattainable by G-banding or FISH. We present a case of a deletion of the 
      derivative chromosome 17 of a t(15;17) in acute promyelocytic leukemia, the size 
      and gene content of which were characterized by a-CGH. We hypothesize that this 
      patient's more aggressive disease course is due to loss of one or more of these 
      genes. Such submicroscopic deletions involving the t(15;17) have only rarely been 
      reported, and, to our knowledge, this is the first case in which a-CGH has been 
      applied to its characterization.
FAU - Dolan, Michelle
AU  - Dolan M
AD  - Department of Laboratory Medicine, Division of Hematology, Oncology and 
      Transplantation, University of Minnesota Medical School, Minneapolis 55455, USA.
FAU - Peterson, Bruce
AU  - Peterson B
FAU - Hirsch, Betsy
AU  - Hirsch B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - IM
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 15/*genetics
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - Middle Aged
MH  - Oligonucleotide Array Sequence Analysis
MH  - Recurrence
MH  - Sequence Deletion
MH  - Translocation, Genetic/*genetics
EDAT- 2008/10/16 09:00
MHDA- 2008/11/05 09:00
CRDT- 2008/10/16 09:00
PHST- 2008/10/16 09:00 [pubmed]
PHST- 2008/11/05 09:00 [medline]
PHST- 2008/10/16 09:00 [entrez]
AID - L120J1K89L805785 [pii]
AID - 10.1309/AJCPENMUI47OGKRW [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2008 Nov;130(5):818-23. doi: 10.1309/AJCPENMUI47OGKRW.