PMID- 18854588
OWN - NLM
STAT- MEDLINE
DCOM- 20090327
LR  - 20240316
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 180
IP  - 4
DP  - 2008 Dec
TI  - Regulation of Caenorhabditis elegans male mate searching behavior by the nuclear 
      receptor DAF-12.
PG  - 2111-22
LID - 10.1534/genetics.108.093773 [doi]
AB  - Coordination of animal behavior with reproductive status is often achieved 
      through elaboration of hormones by the gonad. In the nematode Caenorhabditis 
      elegans, adult males explore their environment to locate mates. Mate searching is 
      regulated by presence of mates, nutritional status, and a signal from the gonad. 
      Here we show that the gonadal signal acts via the nuclear receptor DAF-12, a 
      protein known to regulate several C. elegans life-history traits. DAF-12 has both 
      activational and organizational functions to stimulate exploratory behavior and 
      acts downstream of the gonadal signal, outside of the gonad. DAF-12 acts upstream 
      of sensory input from mating partners and physiological signals indicating 
      nutritional status. Mate searching was rescued in germ-line ablated animals, but 
      not if both germ line and somatic gonad were ablated, by a precursor of the 
      DAF-12 ligand, dafachronic acid (DA). The results are interpreted to suggest that 
      the germ line produces a DA precursor that is converted to DA outside of the germ 
      line, possibly in the somatic gonad. As it does in other pathways in which it 
      functions, in regulation of male mate searching behavior DAF-12 acts at a choice 
      point between alternatives favoring reproduction (mate searching) vs. survival 
      (remaining on food).
FAU - Kleemann, Gunnar
AU  - Kleemann G
AD  - Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 
      10461, USA.
FAU - Jia, Lingyun
AU  - Jia L
FAU - Emmons, Scott W
AU  - Emmons SW
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20081014
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (DAF-12 protein, C elegans)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
SB  - IM
MH  - Animals
MH  - Caenorhabditis elegans/genetics/*physiology
MH  - Caenorhabditis elegans Proteins/*metabolism
MH  - Cell Nucleus/*metabolism
MH  - Female
MH  - Male
MH  - Neurons/metabolism
MH  - Receptors, Cytoplasmic and Nuclear/*metabolism
MH  - Reproduction
MH  - Sexual Behavior, Animal/*physiology
MH  - Signal Transduction
PMC - PMC2600945
EDAT- 2008/10/16 09:00
MHDA- 2009/03/28 09:00
PMCR- 2009/03/01
CRDT- 2008/10/16 09:00
PHST- 2008/10/16 09:00 [entrez]
PHST- 2008/10/16 09:00 [pubmed]
PHST- 2009/03/28 09:00 [medline]
PHST- 2009/03/01 00:00 [pmc-release]
AID - genetics.108.093773 [pii]
AID - gen18042111 [pii]
AID - 10.1534/genetics.108.093773 [doi]
PST - ppublish
SO  - Genetics. 2008 Dec;180(4):2111-22. doi: 10.1534/genetics.108.093773. Epub 2008 
      Oct 14.