PMID- 18855049 OWN - NLM STAT- MEDLINE DCOM- 20090501 LR - 20181113 IS - 0938-8990 (Print) IS - 0938-8990 (Linking) VI - 19 IP - 9 DP - 2008 Sep TI - Quantitative trait loci for porcine baseline erythroid traits at three growth ages in a White Duroc x Erhualian F(2) resource population. PG - 640-6 LID - 10.1007/s00335-008-9142-9 [doi] AB - Baseline erythroid indices are increasingly involved as risk factors for common complex diseases in humans. However, little is known about the genetic architecture of baseline erythroid traits in pigs. In this study, hematocrit (Hct), hemoglobin (Hgb), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), red blood cell (RBC), and red cell distribution width (RDW) were measured in 1420 (day 18), 1410 (day 46), and 1033 (day 240) F(2) pigs from a White Duroc x Erhualian intercross resource population. The entire resource population was genotyped for 183 microsatellite loci across the pig genome, and the quantitative trait loci (QTL) analysis was performed for all erythroid-related traits measured with QTL Express based on a least-squares method. A total of 101 QTL, including 46 genome-wide significant QTL and 55 chromosome-wide significant QTL, regulating erythroid traits were found on all pig chromosomes (SSC) except for SSC15 and SSC18. The genome-wide significant QTL were mainly localized on SSC1, 7, 8, 10, and X. These results confirmed most of QTL previously identified in the swine. More importantly, this study detected age-specific QTL for baseline erythroid traits in pigs for the first time. Notably, the QTL for MCV and MCH on day 18 on SSC8 with small intervals of 3 and 4 cM, respectively, provided a good starting point for identifying causal genes underlying MCV and MCH in the future. FAU - Zou, Zhengzhi AU - Zou Z AD - Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, 330045, China. FAU - Ren, Jun AU - Ren J FAU - Yan, Xueming AU - Yan X FAU - Huang, Xiang AU - Huang X FAU - Yang, Shujin AU - Yang S FAU - Zhang, Zhiyan AU - Zhang Z FAU - Yang, Bin AU - Yang B FAU - Li, Wanbo AU - Li W FAU - Huang, Lusheng AU - Huang L LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20081015 PL - United States TA - Mamm Genome JT - Mammalian genome : official journal of the International Mammalian Genome Society JID - 9100916 RN - 0 (Hemoglobins) SB - IM MH - Age Factors MH - Animals MH - Chromosome Mapping MH - Crosses, Genetic MH - Erythrocyte Indices/*genetics MH - Female MH - Hematocrit MH - Hemoglobins/metabolism MH - Male MH - Phenotype MH - *Quantitative Trait Loci MH - Species Specificity MH - Sus scrofa/*blood/*genetics/growth & development EDAT- 2008/10/16 09:00 MHDA- 2009/05/02 09:00 CRDT- 2008/10/16 09:00 PHST- 2008/06/03 00:00 [received] PHST- 2008/08/25 00:00 [accepted] PHST- 2008/10/16 09:00 [pubmed] PHST- 2009/05/02 09:00 [medline] PHST- 2008/10/16 09:00 [entrez] AID - 10.1007/s00335-008-9142-9 [doi] PST - ppublish SO - Mamm Genome. 2008 Sep;19(9):640-6. doi: 10.1007/s00335-008-9142-9. Epub 2008 Oct 15.