PMID- 18855121
OWN - NLM
STAT- MEDLINE
DCOM- 20090618
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 25
IP  - 2
DP  - 2009 Feb
TI  - Myocardial strain in sub-acute peri-infarct myocardium.
PG  - 151-9
LID - 10.1007/s10554-008-9364-7 [doi]
AB  - PURPOSE: In the absence of additional ischemic insults, the peri-infarct region 
      surrounding the infarct myocardium can recover function. T2 weighted MRI signal 
      is sensitive to edema and used to detect peri-infarct, salvageable myocardium. 
      The main purpose of this study was to investigate the alterations in myocardial 
      strain in the peri-infarct myocardium as compared to normal and infarct 
      myocardium. MATERIALS AND METHODS: Comprehensive MRI of the myocardium was 
      performed in five pigs 6-7 days following coronary artery occlusion-reperfusion 
      myocardial injury. MRI included tagged cine images for myocardial strain, 
      T2weighted (T2w)-images and late gadolinium enhancement (LGE) for assessing 
      myocardial viability. Automated signal intensity thresholds were used to define 
      tissue edema and myocardial infarct. Maximum-shortening strains were analyzed in 
      the infarct, peri-infarct and normal myocardial sectors. The results were 
      correlated with triphenyltetrazolium-chloride (TTC) and hemotoxylin-eosin stained 
      tissue images. RESULTS: We found an excellent correlation of LGE with TTC (r = 
      0.94, P < 0.05). T2w-images markedly overestimated the infarct size (25 +/- 3%). 
      Both the healthy and peri-infarct myocardial sectors had higher myocardial strain 
      than infarct myocardial sectors (P < 0.05). Clear demarcation between infarct and 
      non-infarct myocardium was noted on histology. CONCLUSION: Peri-infarct 
      myocardium continues to demonstrate T2 signal enhancement to at least 7 days, but 
      this region has preserved mechanical function. T2-weighted imaging and myocardial 
      strain measurements provide complementary information and both may be useful for 
      characterization of the peri-infarct myocardium.
FAU - Ruzsics, Balazs
AU  - Ruzsics B
AD  - Department of Biochemistry and Molecular Genetics, University of Alabama, 
      Birmingham, AL, USA.
FAU - Suranyi, Pal
AU  - Suranyi P
FAU - Kiss, Pal
AU  - Kiss P
FAU - Brott, Brigitta C
AU  - Brott BC
FAU - Litovsky, Silvio
AU  - Litovsky S
FAU - Denney, Thomas S Jr
AU  - Denney TS Jr
FAU - Aban, Inmaculada
AU  - Aban I
FAU - Lloyd, Steven G
AU  - Lloyd SG
FAU - Simor, Tamas
AU  - Simor T
FAU - Elgavish, Gabriel A
AU  - Elgavish GA
FAU - Gupta, Himanshu
AU  - Gupta H
LA  - eng
GR  - P50HL077100/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20081015
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Animals
MH  - Contrast Media/administration & dosage
MH  - Gadolinium DTPA/administration & dosage
MH  - Image Processing, Computer-Assisted
MH  - Linear Models
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Myocardial Infarction/*physiopathology
MH  - Myocardium/pathology
MH  - Swine
EDAT- 2008/10/16 09:00
MHDA- 2009/06/19 09:00
CRDT- 2008/10/16 09:00
PHST- 2007/11/27 00:00 [received]
PHST- 2008/08/14 00:00 [accepted]
PHST- 2008/10/16 09:00 [pubmed]
PHST- 2009/06/19 09:00 [medline]
PHST- 2008/10/16 09:00 [entrez]
AID - 10.1007/s10554-008-9364-7 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2009 Feb;25(2):151-9. doi: 10.1007/s10554-008-9364-7. 
      Epub 2008 Oct 15.