PMID- 18855223
OWN - NLM
STAT- MEDLINE
DCOM- 20090320
LR  - 20090209
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 69
IP  - 1
DP  - 2009
TI  - Release patterns of pregnancy-associated plasma protein A in patients with acute 
      coronary syndromes assessed by an optimized monoclonal antibody assay.
PG  - 121-7
LID - 10.1080/00365510802439080 [doi]
AB  - OBJECTIVE: Pregnancy-associated plasma protein A (PAPP-A) is expressed in eroded 
      and ruptured atheromatous plaques, and circulating levels are elevated in acute 
      coronary syndromes (ACS). Our objective was to investigate release patterns of 
      PAPP-A in ACS and whether they differ among different types of ACS. METHODS: In 
      40 patients, PAPP-A concentrations were measured in serially collected samples 
      assessed by a novel ELISA technique. The patients were grouped according to type 
      of ACS. RESULTS: Release patterns for ST elevation myocardial infarction (STEMI) 
      patients who underwent primary percutaneous coronary intervention (pPCI) showed a 
      single substantial PAPP-A increase shortly after pPCI, followed by an abrupt 
      return to normal levels without secondary peaks. STEMI, high-risk and low-risk 
      non-ST elevation myocardial infarction/unstable angina pectoris (NSTEMI/UAP) 
      patients without pPCI showed highly variable patterns with primary peaks followed 
      by secondary PAPP-A increases. All patients with elevated PAPP-A levels reached 
      the upper reference level within 24 h. There was a significant difference in 
      median peak levels between STEMI (23.2 mIU/L) and low-risk ACS patients (6.35 
      mIU/L) (p = 0.004) and between high-risk (median = 15.3 mIU/L) and low-risk ACS 
      patients (p = 0.01). Among high-risk ACS patients, NSTEMI patients had 
      significantly higher peak levels than UAP patients (p = 0.003). CONCLUSION: 
      PAPP-A serum levels increase above normal values within 24 h after onset of 
      symptoms in ACS. There are significant differences in PAPP-A peak levels and 
      release patterns across the spectrum of ACS patients.
FAU - Schoos, Mikkel
AU  - Schoos M
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen, Denmark.
FAU - Iversen, Kasper
AU  - Iversen K
FAU - Teisner, Ane
AU  - Teisner A
FAU - Teisner, Borge
AU  - Teisner B
FAU - Thaning, Pia
AU  - Thaning P
FAU - Kliem, Anette
AU  - Kliem A
FAU - Grande, Peer
AU  - Grande P
FAU - Clemmensen, Peter
AU  - Clemmensen P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (Antibodies, Monoclonal)
RN  - EC 3.4.24.- (Pregnancy-Associated Plasma Protein-A)
SB  - IM
MH  - Acute Coronary Syndrome/*metabolism
MH  - Aged
MH  - Antibodies, Monoclonal/*immunology
MH  - Female
MH  - Humans
MH  - Immunoassay/*methods
MH  - Male
MH  - Middle Aged
MH  - Pregnancy-Associated Plasma Protein-A/*metabolism
EDAT- 2008/10/16 09:00
MHDA- 2009/03/21 09:00
CRDT- 2008/10/16 09:00
PHST- 2008/10/16 09:00 [pubmed]
PHST- 2009/03/21 09:00 [medline]
PHST- 2008/10/16 09:00 [entrez]
AID - 904097983 [pii]
AID - 10.1080/00365510802439080 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2009;69(1):121-7. doi: 10.1080/00365510802439080.