PMID- 18855243
OWN - NLM
STAT- MEDLINE
DCOM- 20081229
LR  - 20240312
IS  - 1097-9891 (Electronic)
IS  - 0095-2990 (Print)
IS  - 0095-2990 (Linking)
VI  - 34
IP  - 6
DP  - 2008
TI  - Signal-averaged electrocardiogram in physically healthy, chronic 
      3,4-methylenedioxymethamphetamine (MDMA) users.
PG  - 712-20
LID - 10.1080/00952990802308254 [doi]
AB  - OBJECTIVES: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) use has been 
      associated with cardiac arrhythmias. Markers of ventricular late potentials 
      (VLP), which may be a precursor to malignant ventricular arrhythmias, can be 
      detected by signal-averaged electrocardiography (SA-ECG), but not by standard 
      ECG. METHODS: We evaluated SA-ECG parameters in 21 physically healthy, recently 
      abstinent MDMA users who also used cannabis (11 males, mean [SD] age 23.3 [4.6] 
      years, 2.8 [2.0] years of use), 18 physically healthy cannabis users (8 males, 
      mean [SD] age 26.6 [7.1] years, 11.2 [5.4] years of use) and 54 non-drug-using 
      controls (21 males, mean [SD] age 28.4 [7.8] years). We analyzed three SA-ECG 
      parameters considered markers of VLPs: duration of filtered QRS complex (fQRS), 
      duration of low amplitude potentials during terminal 40 ms of QRS complex 
      (LAS40), and root mean square voltage during terminal 40 ms of QRS complex 
      (RMS40). RESULTS: MDMA users, cannabis users, and non-drug-using controls did not 
      differ significantly from each other in fQRS, LAS40, or RMS40 values or in the 
      proportion of subjects with abnormal SA-ECG parameters. There were significant 
      gender differences among controls, but not among MDMA users. CONCLUSION: These 
      findings suggest that chronic MDMA use is neither quantitatively nor 
      qualitatively associated with a high prevalence of abnormal SA-ECG parameters 
      indicative of VLP markers.
FAU - Kanneganti, Praveen
AU  - Kanneganti P
AD  - Intramural Research Program, Department of Health and Human Services, National 
      Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
FAU - Huestis, Marilyn A
AU  - Huestis MA
FAU - Kolbrich, Erin A
AU  - Kolbrich EA
FAU - Goodwin, Robert
AU  - Goodwin R
FAU - Ziegelstein, Roy C
AU  - Ziegelstein RC
FAU - Gorelick, David A
AU  - Gorelick DA
LA  - eng
GR  - Z01 DA000240-15/Intramural NIH HHS/United States
GR  - Z01 DA000241-15/Intramural NIH HHS/United States
GR  - Z01 DA000468-04/Intramural NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - England
TA  - Am J Drug Alcohol Abuse
JT  - The American journal of drug and alcohol abuse
JID - 7502510
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Arrhythmias, Cardiac/*diagnosis/etiology
MH  - Electrocardiography/*methods
MH  - Female
MH  - Hallucinogens/*adverse effects
MH  - Humans
MH  - Male
MH  - Marijuana Abuse/physiopathology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Prevalence
MH  - Sex Factors
MH  - Young Adult
PMC - PMC2587117
MID - NIHMS58546
COIS- The authors have no conflicts of interest to declare.
EDAT- 2008/10/16 09:00
MHDA- 2008/12/30 09:00
PMCR- 2009/01/01
CRDT- 2008/10/16 09:00
PHST- 2008/10/16 09:00 [pubmed]
PHST- 2008/12/30 09:00 [medline]
PHST- 2008/10/16 09:00 [entrez]
PHST- 2009/01/01 00:00 [pmc-release]
AID - 904099373 [pii]
AID - 10.1080/00952990802308254 [doi]
PST - ppublish
SO  - Am J Drug Alcohol Abuse. 2008;34(6):712-20. doi: 10.1080/00952990802308254.