PMID- 1886997
OWN - NLM
STAT- MEDLINE
DCOM- 19911010
LR  - 20061115
IS  - 0033-8192 (Print)
IS  - 0033-8192 (Linking)
VI  - 31
IP  - 3
DP  - 1991 May-Jun
TI  - [The effect of low doses of ionizing radiation on the intermediate filaments and 
      the Ca2+-activated proteolysis system in the rat brain].
PG  - 333-9
AB  - The immunochemical methods were used to study the effect of low-level radiation 
      (0.00645 C/kg and 0.0129 C/kg) on the content and polypeptide composition of 
      glial intermediate filament proteins (GIFP) in different rat brain areas. Changes 
      in glial fibrillar acidic protein (GFAP) concentration were more significant with 
      the dose of 0.0129 C/kg than 0.00645 C/kg. It is suggested that soluble GIFP is 
      more susceptible to the effect of Ca(2+)-dependent proteinases, calpains, than 
      the filament one is, and degrades as early as the first few hours following 
      irradiation. However, low radiation doses were ineffective with respect to 
      calpains activity in the animal brain. The increased Ca2+ concentration enhances 
      considerably GFAP degradation under the effect of calpains I and II. It is 
      suggested that with low radiation doses the rearrangements of glial intermediate 
      filaments may occur due to activation of calpains by releasing Ca ions.
FAU - Nedzvetskii, V S
AU  - Nedzvetskii VS
FAU - Ushakova, G A
AU  - Ushakova GA
FAU - Busygina, S G
AU  - Busygina SG
FAU - Berezin, V A
AU  - Berezin VA
FAU - Dvoretskii, A I
AU  - Dvoretskii AI
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Vliianie malykh doz ioniziruiushchei radiatsii na promezhutochnye filamenty i 
      Ca2+-aktiviruemuiu sistemy proteoliza golovnogo mozga krysy.
PL  - Russia (Federation)
TA  - Radiobiologiia
JT  - Radiobiologiia
JID - 0401251
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - EC 3.4.22.- (Calpain)
SB  - IM
MH  - Animals
MH  - Brain/metabolism/*radiation effects
MH  - Calpain/*biosynthesis/physiology
MH  - Glial Fibrillary Acidic Protein/*metabolism
MH  - Radiation Dosage
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1991/05/01 00:00
MHDA- 1991/05/01 00:01
CRDT- 1991/05/01 00:00
PHST- 1991/05/01 00:00 [pubmed]
PHST- 1991/05/01 00:01 [medline]
PHST- 1991/05/01 00:00 [entrez]
PST - ppublish
SO  - Radiobiologiia. 1991 May-Jun;31(3):333-9.