PMID- 1889893
OWN - NLM
STAT- MEDLINE
DCOM- 19911017
LR  - 20171206
IS  - 0391-3988 (Print)
IS  - 0391-3988 (Linking)
VI  - 14
IP  - 7
DP  - 1991 Jul
TI  - In vivo comparative evaluation of hemodialysis tubing plasticized with DEHP and 
      TEHTM.
PG  - 407-10
AB  - The migration of plasticizers from blood lines was studied in 11 patients with 
      chronic renal failure on hemodialysis for a period of six months. 
      Di-2-ethylhexylphthalate (DEHP), the conventional plasticizer, was compared with 
      tri-2-ethylhexyltrimellitate (TEHTM). A liquid chromatography method for 
      quantitative determination of DEHP and TEHTM in human blood plasma is described. 
      During treatment with tubing containing DEHP, the plasma level of DEHP rose from 
      0.10 micrograms/ml (less than 0.05-0.17 n = 11) to 0.70 micrograms/ml (0.30-1.6 n 
      = 11). When the patients were changed to tubing containing TEHTM, the 
      concentration of DEHP was below or close to the detection limit and TEHTM could 
      not be detected. No adverse events of either tubing were found as regards acute 
      toxic effects, performance or applicability.
FAU - Christensson, A
AU  - Christensson A
AD  - Department of Medicine, Malmo General Hospital, Sweden.
FAU - Ljunggren, L
AU  - Ljunggren L
FAU - Nilsson-Thorell, C
AU  - Nilsson-Thorell C
FAU - Arge, B
AU  - Arge B
FAU - Diehl, U
AU  - Diehl U
FAU - Hagstam, K E
AU  - Hagstam KE
FAU - Lundberg, M
AU  - Lundberg M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Artif Organs
JT  - The International journal of artificial organs
JID - 7802649
RN  - 0 (Benzoates)
RN  - 0 (Plasticizers)
RN  - 3319-31-1 (tri-(2-ethylhexyl)trimellitate)
RN  - 9002-86-2 (Polyvinyl Chloride)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Aged
MH  - Benzoates/*analysis/toxicity
MH  - Chromatography, Liquid
MH  - Diethylhexyl Phthalate/*analysis/toxicity
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Kidney Failure, Chronic/therapy
MH  - Male
MH  - Plasticizers/*analysis/toxicity
MH  - Polyvinyl Chloride
MH  - Renal Dialysis/*instrumentation
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
PST - ppublish
SO  - Int J Artif Organs. 1991 Jul;14(7):407-10.