PMID- 18922539
OWN - NLM
STAT- MEDLINE
DCOM- 20090122
LR  - 20191210
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1211
IP  - 1-2
DP  - 2008 Nov 21
TI  - Speciation of butyltin compounds in environmental and biological samples using 
      headspace single drop microextraction coupled with gas chromatography-inductively 
      coupled plasma mass spectrometry.
PG  - 135-41
LID - 10.1016/j.chroma.2008.09.089 [doi]
AB  - A method based on headspace single drop microextraction (HS-SDME) in combination 
      with gas chromatography-inductively coupled plasma mass spectrometry (GC-ICP-MS) 
      was proposed for the speciation analysis of butyltin compounds in environmental 
      and biological samples. The sodium tetraethylborate (NaBEt4) and sodium 
      tetrahydroborate (NaBH4) were used as the derivatizing reagent for in situ 
      derivatization of the butyltins. For the two derivatizations, the HS-SDME 
      parameters such as organic solvent, drop volume, sample pH, stirring rate, 
      temperature, extraction time and the ionic strength were examined systematically. 
      The analytical performance including the linearity ranges, limits of detection 
      (LODs) and reproducibilities of the two derivatizations were compared under the 
      respective optimized conditions. Derivatization with NaBEt(4) proved to be more 
      sensitive and robust than that with NaBH4, leading to the LODs of 1.4 ng/L for 
      MBT, 1.8 ng/L for DBT and 0.8 ng/L for TBT. The reproducibilities, expressed as 
      relative standard deviations (RSDs), were in the range of 1.1-5.3% (c=1 microg/L, 
      n=3). With tripropyltin (TPrT) as internal standard, HS-SDME-GC-ICP-MS with 
      NaBEt(4) derivatization was applied for the speciation analysis of butyltins in 
      real seawater and shellfish samples. The butyltins found in the real-world 
      samples are 31ng/L MBT, 79 ng/L DBT and 32 ng/L TBT for seawater, and 11.6-30.4 
      ng/g MBT, 11.8-8.9 ng/g DBT and 12.8-52.6 ng/g TBT for different shellfish 
      samples. For validation, the developed method was also employed for the 
      speciation analysis of butyltins in certified reference material (CRM) of PACS-2 
      sediment, and the determined values are in a good agreement with the certified 
      values. The developed method is simple, rapid, sensitive, and cost-effective and 
      provides an attractive alternative for butyltins speciation in biological and 
      environmental samples with complex matrix.
FAU - Xiao, Qin
AU  - Xiao Q
AD  - Department of Chemistry, Wuhan University, Wuhan 430072, China.
FAU - Hu, Bin
AU  - Hu B
FAU - He, Man
AU  - He M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081002
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Borates)
RN  - 0 (Borohydrides)
RN  - 0 (Organotin Compounds)
RN  - 0 (Solvents)
RN  - 15523-24-7 (sodium tetraethylborate)
RN  - 87L0B9CPPA (sodium borohydride)
SB  - IM
MH  - Animals
MH  - Borates/chemical synthesis
MH  - Borohydrides/chemical synthesis
MH  - Chemical Fractionation/*methods
MH  - Gas Chromatography-Mass Spectrometry/economics/methods
MH  - Hydrogen-Ion Concentration
MH  - Organotin Compounds/*analysis
MH  - Osmolar Concentration
MH  - Reference Standards
MH  - Reproducibility of Results
MH  - Seawater/*chemistry
MH  - Sensitivity and Specificity
MH  - Shellfish/*analysis
MH  - Solvents/chemistry
MH  - Temperature
EDAT- 2008/10/17 09:00
MHDA- 2009/01/23 09:00
CRDT- 2008/10/17 09:00
PHST- 2008/08/08 00:00 [received]
PHST- 2008/09/23 00:00 [revised]
PHST- 2008/09/26 00:00 [accepted]
PHST- 2008/10/17 09:00 [pubmed]
PHST- 2009/01/23 09:00 [medline]
PHST- 2008/10/17 09:00 [entrez]
AID - S0021-9673(08)01683-X [pii]
AID - 10.1016/j.chroma.2008.09.089 [doi]
PST - ppublish
SO  - J Chromatogr A. 2008 Nov 21;1211(1-2):135-41. doi: 10.1016/j.chroma.2008.09.089. 
      Epub 2008 Oct 2.