PMID- 18923157
OWN - NLM
STAT- MEDLINE
DCOM- 20090327
LR  - 20181113
IS  - 0006-3363 (Print)
IS  - 1529-7268 (Electronic)
IS  - 0006-3363 (Linking)
VI  - 80
IP  - 2
DP  - 2009 Feb
TI  - Endometriosis is associated with progesterone resistance in the baboon (Papio 
      anubis) oviduct: evidence based on the localization of oviductal glycoprotein 1 
      (OVGP1).
PG  - 272-8
LID - 10.1095/biolreprod.108.072496 [doi]
AB  - Endometriosis has been associated with a reduced response to progesterone in both 
      the eutopic and ectopic endometrium. In this study we evaluated OVGP1 and steroid 
      receptor expression in oviducts of baboons with endometriosis during the 
      midsecretory phase and determined whether progesterone resistance associated with 
      endometriosis also occurs in the oviduct. Oviducts obtained during the window of 
      uterine receptivity (Day 10 postovulation [PO]) from animals with induced and 
      spontaneous disease were compared to control animals during the proliferative 
      stage and in the implantation window as well as animals treated with the 
      progesterone receptor (PGR) antagonist ZK 137.299 (ZK). OVGP1 was significantly 
      higher in animals with endometriosis compared with Day 10 PO controls and was 
      similar to that seen in the late proliferative phase and in ZK-treated animals. 
      Baboons with spontaneous endometriosis also showed a similar persistence of 
      OVGP1, which was correlated with the maintenance of estrogen receptor 1 (ESR1) in 
      the epithelial cells of animals with endometriosis. However, epithelial cell 
      height and the percentage of ciliation were not affected by endometriosis. These 
      data imply that the normal antagonism of progesterone on ESR and OVGP1, which 
      results in their downregulation during the window of implantation, is absent in 
      animals with endometriosis. This was confirmed further when the action of PGR was 
      antagonized in animals without disease, which also resulted in the persistence of 
      ESR1 and OVGP1. These studies suggest that an aberrant oviductal environment may 
      be an additive factor that contributes to endometriosis-associated infertility.
FAU - Wang, Chaohua
AU  - Wang C
AD  - Department of Obstetrics and Gynecology, The People's Hospital, Beijing 
      University, Beijing 10004, China.
FAU - Mavrogianis, Patricia A
AU  - Mavrogianis PA
FAU - Fazleabas, Asgerally T
AU  - Fazleabas AT
LA  - eng
GR  - U54 HD040093/HD/NICHD NIH HHS/United States
GR  - U54 HD040093-07/HD/NICHD NIH HHS/United States
GR  - U54 HD 40093/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20081015
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Glycoproteins)
RN  - 0 (Receptors, Progesterone)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - Drug Resistance/*physiology
MH  - Endometriosis/*etiology/metabolism/pathology
MH  - Endometrium/metabolism/pathology
MH  - Estrogen Receptor alpha/metabolism
MH  - Fallopian Tubes/drug effects/*metabolism
MH  - Female
MH  - Glycoproteins/*metabolism
MH  - Papio anubis
MH  - Peritoneal Diseases/*etiology/metabolism/pathology
MH  - Progesterone/*pharmacology
MH  - Receptors, Progesterone/metabolism
MH  - Tissue Distribution
PMC - PMC2662730
MID - NIHMS94411
EDAT- 2008/10/17 09:00
MHDA- 2009/03/28 09:00
PMCR- 2010/02/01
CRDT- 2008/10/17 09:00
PHST- 2008/10/17 09:00 [pubmed]
PHST- 2009/03/28 09:00 [medline]
PHST- 2008/10/17 09:00 [entrez]
PHST- 2010/02/01 00:00 [pmc-release]
AID - biolreprod.108.072496 [pii]
AID - 10.1095/biolreprod.108.072496 [doi]
PST - ppublish
SO  - Biol Reprod. 2009 Feb;80(2):272-8. doi: 10.1095/biolreprod.108.072496. Epub 2008 
      Oct 15.