PMID- 18923993
OWN - NLM
STAT- MEDLINE
DCOM- 20081030
LR  - 20161124
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 71
IP  - 23
DP  - 2008
TI  - Percutaneous absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from soil.
PG  - 1509-15
LID - 10.1080/15287390802349875 [doi]
AB  - Eight dermal absorption experiments (two in vivo; six in vitro) and one 
      intravenous experiment were conducted using 2,3,7,8-tetrachlorodibenzo-p-dioxin 
      (TCDD) either neat (high dose at approximately 250 microg/cm(2) and low dose at 
      10 ng/cm(2)) or sorbed on a low organic soil (LOS) or high organic soil (HOS) at 
      1 ppm (10 ng TCDD/10 mg soil/cm(2)). After 96 h the percent of applied dose 
      absorbed (PADA) for the neat low dose was 78% in vivo (rat) and 76% in vitro 
      (rat). PADA for the equivalent TCDD dose sorbed on LOS were 16.3% (rat in vivo), 
      7.7% (rat in vitro) and 2.4% (human in vitro). The PADA for TCDD sorbed on HOS (1 
      ppm) was 1.0% (rat in vitro). Generally, rat skin was observed to be three to 
      four times more permeable to TCDD than human skin. At steady state, the dermal 
      flux of TCDD in neat form, sorbed on LOS at 1 ppm, and sorbed on HOS at 1 ppm 
      (all in vitro, rat) was 120, 0.007, and 0.0007 ng/cm(2)/h, respectively (ratio = 
      1.7 x 10(5):10:1). Making adjustments to account for differences between in vitro 
      and in vivo results and adjusting for application to monolayer loads, the 24-h 
      TCDD absorption for human skin is estimated as 1.9% from LOS (1 ppm) and 0.24% 
      from HOS (1 ppm).
FAU - Roy, Timothy A
AU  - Roy TA
AD  - Port Royal Research, Hilton Head, South Carolina, USA.
FAU - Hammerstrom, Karen
AU  - Hammerstrom K
FAU - Schaum, John
AU  - Schaum J
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Soil Pollutants)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Injections, Intravenous
MH  - Polychlorinated Dibenzodioxins/administration & dosage/*pharmacokinetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Skin Absorption
MH  - Soil Pollutants/administration & dosage/*pharmacokinetics
EDAT- 2008/10/17 09:00
MHDA- 2008/10/31 09:00
CRDT- 2008/10/17 09:00
PHST- 2008/10/17 09:00 [pubmed]
PHST- 2008/10/31 09:00 [medline]
PHST- 2008/10/17 09:00 [entrez]
AID - 904188971 [pii]
AID - 10.1080/15287390802349875 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2008;71(23):1509-15. doi: 10.1080/15287390802349875.