PMID- 18924309
OWN - NLM
STAT- MEDLINE
DCOM- 20081204
LR  - 20081017
IS  - 0392-4203 (Print)
IS  - 0392-4203 (Linking)
VI  - 79 Suppl 1
DP  - 2008
TI  - Metallic elements in pulmonary biopsies from lung cancer and control subjects.
PG  - 43-51
AB  - Occupational/environmental exposure to some metallic elements is a risk factor 
      for the development of lung diseases, including lung cancer. We aimed at 
      investigating the levels of arsenic, beryllium, cadmium, cobalt, chromium, nickel 
      and lead in the lung tissue of patients affected by early stage non small cell 
      lung cancer (NSCLC). A small number of patients without a diagnosis of lung 
      cancer were also included as control group. Lung tissue biopsies were collected 
      from 45 NSCLC patients (both cancerous and unaffected tissues) and 8 control 
      subjects undergoing surgery. Patients were stratified for smoking habits, 
      histopathology and cancer sites. Metallic elements were determined in dry tissue 
      after digestion by means of ICP-MS. Cd, Ni and Pb levels were higher in 
      unaffected than in control tissues (0.52 vs 0.18 microg/g dry, p < 0.05 for Cd; 
      4.49 vs 1.8 microg/g dry,p < 0.05 for Ni; 0.21 vs 0.06 microg/g dry, p < 0.01 for 
      Pb). The three elements, and particularly Cd, were influenced by smoking habits; 
      Pb levels were higher in squamocellular carcinoma than adenocarcinomas; Ni 
      distributed in the lungs in an inhomogeneous way. This study demonstrates that 
      the unaffected lung tissue is more representative than the cancerous tissue of 
      the pulmonary content of metallic elements. Tobacco smoke is a main factor 
      affecting the concentration levels of Cd, Pb, and to a lesser extent Ni in the 
      lung tissues of NSCLC patients. The role of past environmental-occupational 
      exposures could not be fully elucidated, due to the limited sample size and the 
      retrospective nature of the study.
FAU - De Palma, Giuseppe
AU  - De Palma G
AD  - Department of Experimental and Applied Medicine, Section of Industrial Hygiene, 
      University of Brescia, Brescia, Italy. depalma@med.unibs.it
FAU - Goldoni, Matteo
AU  - Goldoni M
FAU - Catalani, Simona
AU  - Catalani S
FAU - Carbognani, Paolo
AU  - Carbognani P
FAU - Poli, Diana
AU  - Poli D
FAU - Mozzoni, Paola
AU  - Mozzoni P
FAU - Acampa, Olga
AU  - Acampa O
FAU - Internullo, Eveline
AU  - Internullo E
FAU - Rusca, Michele
AU  - Rusca M
FAU - Apostoli, Pietro
AU  - Apostoli P
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Acta Biomed
JT  - Acta bio-medica : Atenei Parmensis
JID - 101295064
RN  - 0 (Metals)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Carcinoma, Non-Small-Cell Lung/*chemistry/*pathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*chemistry/*pathology
MH  - Male
MH  - Metals/*analysis
MH  - Middle Aged
EDAT- 2008/10/18 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/10/18 09:00
PHST- 2008/10/18 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/10/18 09:00 [entrez]
PST - ppublish
SO  - Acta Biomed. 2008;79 Suppl 1:43-51.