PMID- 18924311
OWN - NLM
STAT- MEDLINE
DCOM- 20081204
LR  - 20081017
IS  - 0392-4203 (Print)
IS  - 0392-4203 (Linking)
VI  - 79 Suppl 1
DP  - 2008
TI  - Breath analysis in non small cell lung cancer patients after surgical tumour 
      resection.
PG  - 64-72
AB  - Exhaled volatile organic compounds (VOCs), mainly aliphatic and aromatic 
      hydrocarbons, have been proposed as a diagnostic test for early lung cancer 
      detection, but the effect of lung cancer surgical re-moval on exhaled VOCs 
      pattern has never been specifically addressed. The aim of this study was to 
      compare VOC levels measured in non small cell lung cancer (NSCLC) patients before 
      surgery (T0), one month (T1) and 3 years (T2) after surgical removal of tumour. 
      In order to better understand the pathophysiological meaning of exhaled aromatic 
      hydrocarbons, the same exhaled biomarkers were also assessed in cancerous and 
      macroscopically unaffected lung tissue samples collected during surgical 
      operation. Exhaled breath was collected in a specially designed Teflon bulb 
      trapping the last 150 ml of a single slow vital capacity. After solid phase 
      micro-extraction, VOCs were analysed in gas chromatography-mass spectrometry. VOC 
      levels were unaffected by surgical removal, except for isoprene, whose 
      concentration was significantly reduced. Three years after surgical operation, 
      some VOCs significantly changed from baseline: in particular, we noted a decrease 
      in isoprene and benzene concentrations, whereas the levels of pentane, toluene 
      and ethylbenzene were increased in comparison with baseline values. Finally, lung 
      tissue analysis showed that all aromatic hydrocarbons, except xylenes, were 
      significantly higher in cancerous than in unaffected tissue. This study showed 
      that surgical operation can influence the concentration of some exhaled VOCs 
      opening a new scenario in the use of exhaled VOCs in lung cancer patients, not 
      only for diagnostic but also for follow up purposes.
FAU - Poli, Diana
AU  - Poli D
AD  - ISPESL Research Center at the University of Parma, Italy.
FAU - Goldoni, Matteo
AU  - Goldoni M
FAU - Caglieri, Andrea
AU  - Caglieri A
FAU - Ceresa, Giorgia
AU  - Ceresa G
FAU - Acampa, Olga
AU  - Acampa O
FAU - Carbognani, Paolo
AU  - Carbognani P
FAU - Rusca, Michele
AU  - Rusca M
FAU - Corradi, Massimo
AU  - Corradi M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Italy
TA  - Acta Biomed
JT  - Acta bio-medica : Atenei Parmensis
JID - 101295064
RN  - 0 (Volatile Organic Compounds)
SB  - IM
MH  - Aged
MH  - Breath Tests
MH  - Carcinoma, Non-Small-Cell Lung/*metabolism/*surgery
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*metabolism/*surgery
MH  - Male
MH  - Middle Aged
MH  - Volatile Organic Compounds/*analysis/*metabolism
EDAT- 2008/10/18 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/10/18 09:00
PHST- 2008/10/18 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/10/18 09:00 [entrez]
PST - ppublish
SO  - Acta Biomed. 2008;79 Suppl 1:64-72.