PMID- 18925886
OWN - NLM
STAT- MEDLINE
DCOM- 20090707
LR  - 20151119
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 63
IP  - 11
DP  - 2008 Nov
TI  - Specific IgE to allergens in cord blood is associated with maternal immunity to 
      Toxoplasma gondii and rubella virus.
PG  - 1505-11
LID - 10.1111/j.1398-9995.2008.01793.x [doi]
AB  - BACKGROUND: Various studies have found reduced prevalences of atopic 
      sensitization and atopic diseases in children previously exposed to infections or 
      living conditions with a high microbial burden, such as the farming environment. 
      OBJECTIVE: We sought to determine the relationships of cord blood immunoglobulin 
      E (IgE) with maternal health conditions before and during pregnancy. METHODS: 
      Pregnant women living in rural areas in five European countries were recruited in 
      the third trimester of pregnancy. Information on maternal health during pregnancy 
      was collected from maternity records and by questionnaires (n = 497). Specific 
      IgE for inhalant and food allergens was assessed in cord blood and peripheral 
      blood samples of the mothers. RESULTS: Inverse associations of cord blood IgE to 
      seasonal allergens with positive maternal records for Toxoplasma gondii (adjusted 
      odds ratio = 0.37 [0.17-0.81]) and rubella virus (adjusted odds ratio = 0.35 
      [0.13-0.96]) were found. The previously described effect of prenatal farm 
      exposure on IgE to seasonal allergens was partly confounded by a positive 
      maternal record for T. gondii. The number of maternal siblings, maternal contact 
      to cats during pregnancy or during her first year of life, predicted a positive 
      maternal record for T. gondii. CONCLUSIONS: Maternal immunity to T. gondii and 
      rubella may impact on atopic sensitization in the fetus. A positive T. gondii 
      record explained the previously identified effect of prenatal farm exposure on 
      IgE to seasonal allergens only to a minor extent.
FAU - Ege, M J
AU  - Ege MJ
AD  - University Children's Hospital, Munich, Germany.
FAU - Herzum, I
AU  - Herzum I
FAU - Buchele, G
AU  - Buchele G
FAU - Krauss-Etschmann, S
AU  - Krauss-Etschmann S
FAU - Lauener, R P
AU  - Lauener RP
FAU - Bitter, S
AU  - Bitter S
FAU - Roponen, M
AU  - Roponen M
FAU - Remes, S
AU  - Remes S
FAU - Vuitton, D A
AU  - Vuitton DA
FAU - Riedler, J
AU  - Riedler J
FAU - Brunekreef, B
AU  - Brunekreef B
FAU - Dalphin, J-C
AU  - Dalphin JC
FAU - Braun-Fahrlander, C
AU  - Braun-Fahrlander C
FAU - Pekkanen, J
AU  - Pekkanen J
FAU - Renz, H
AU  - Renz H
FAU - von Mutius, E
AU  - von Mutius E
CN  - PASTURE Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Female
MH  - Fetal Blood/*immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/*immunology/microbiology/virology
MH  - Immunoglobulin E/*blood
MH  - Pregnancy
MH  - Rubella/*immunology
MH  - Rubella virus/*immunology
MH  - Surveys and Questionnaires
MH  - Toxoplasma/*immunology
MH  - Toxoplasmosis/*immunology
FIR - Weiss, Gertraud
IR  - Weiss G
FIR - Ublagger, Ellen
IR  - Ublagger E
FIR - Humer, Claudia
IR  - Humer C
FIR - Russegger, Manuela
IR  - Russegger M
FIR - Juntunen, Raija
IR  - Juntunen R
FIR - Tiihonen, Reetta
IR  - Tiihonen R
FIR - Tiittanen, Pekka
IR  - Tiittanen P
FIR - Hirvonen, Maija-Riitta
IR  - Hirvonen MR
FIR - Huttunen, Kati
IR  - Huttunen K
FIR - Virtanen, Suvi
IR  - Virtanen S
FIR - Kauppila, Timo
IR  - Kauppila T
FIR - Nevalainen, Aino
IR  - Nevalainen A
FIR - Hyvarinen, Anne
IR  - Hyvarinen A
FIR - Tuomainen, Tomi-Pekka
IR  - Tuomainen TP
FIR - Karvonen, Anne
IR  - Karvonen A
FIR - Dalphin, Marie-Laure
IR  - Dalphin ML
FIR - Piarroux, Renaud
IR  - Piarroux R
FIR - Reboux, Gabriel
IR  - Reboux G
FIR - Roussel, Sandrine
IR  - Roussel S
FIR - Sudre, Bertrand
IR  - Sudre B
FIR - Schmid, Susanne
IR  - Schmid S
FIR - Illi, Sabina
IR  - Illi S
FIR - Korherr, Nicola
IR  - Korherr N
FIR - Genuneit, Jon
IR  - Genuneit J
FIR - Peter, Richard
IR  - Peter R
FIR - Sel, Serdar
IR  - Sel S
FIR - Blumer, Nicole
IR  - Blumer N
FIR - Pfefferle, Petra
IR  - Pfefferle P
FIR - Gehring, Ulrike
IR  - Gehring U
FIR - Sennhauser, Felix H
IR  - Sennhauser FH
FIR - Loeliger, Susanne
IR  - Loeliger S
FIR - Steinle, Johanna
IR  - Steinle J
FIR - Frei, Remo
IR  - Frei R
EDAT- 2008/10/18 09:00
MHDA- 2009/07/08 09:00
CRDT- 2008/10/18 09:00
PHST- 2008/10/18 09:00 [pubmed]
PHST- 2009/07/08 09:00 [medline]
PHST- 2008/10/18 09:00 [entrez]
AID - ALL1793 [pii]
AID - 10.1111/j.1398-9995.2008.01793.x [doi]
PST - ppublish
SO  - Allergy. 2008 Nov;63(11):1505-11. doi: 10.1111/j.1398-9995.2008.01793.x.