PMID- 18925890
OWN - NLM
STAT- MEDLINE
DCOM- 20090707
LR  - 20151119
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 63
IP  - 11
DP  - 2008 Nov
TI  - IgE antibodies to omega-5 gliadin associate with immediate symptoms on oral wheat 
      challenge in Japanese children.
PG  - 1536-42
LID - 10.1111/j.1398-9995.2008.01753.x [doi]
AB  - BACKGROUND: Gliadins have been implicated in immunoglobulin E (IgE)-mediated 
      allergy to ingested wheat and omega-5-gliadin is known to represent a major 
      allergen in wheat-dependent exercise-induced anaphylaxis. Less known is whether 
      omega-5-gliadin is a clinically relevant allergen in children with immediate 
      allergy to ingested wheat. This study investigates whether specific IgE 
      antibodies to omega-5-gliadin (sIgE-omega-5-gliadin-ab) could be used as a marker 
      for oral wheat challenge outcome in wheat-sensitized children. A secondary 
      objective was to study whether the level of sIgE-omega-5-gliadin was related to 
      symptom severity in children with a positive challenge test. METHODS: Serum 
      samples from 88 children sensitized to wheat, of whom 35 underwent wheat 
      challenge, were collected consecutively. sIgE-omega-5-gliadin-ab was related to a 
      physician's diagnosis of wheat allergy and challenge symptoms. RESULTS: The mean 
      concentration of sIgE-omega-5-gliadin-ab was 7.25 kU(A)/l in patients with wheat 
      allergy and 1.08 kU(A)/l in patients with no wheat allergy (P < 0.01). 
      sIgE-omega-5-gliadin-ab was only detected in 12 of the non-wheat allergic 
      children and 11 of them had a specific IgE to wheat below 1.30 kU(A)/l. Children 
      reacting with severe symptoms upon challenge (n = 8) had increased levels of 
      sIgE-omega-5-gliadin-ab compared to children with moderate, mild or no symptoms 
      (P < 0.001). CONCLUSIONS: The presence of sIgE-omega-5-gliadin-ab is related to 
      the reaction level to wheat challenge outcome in wheat-sensitized children. The 
      sIgE-omega-5-gliadin-ab was found to be associated with a strong convincing 
      history of wheat allergy also in those cases when oral food challenge was 
      avoided. The sIgE-omega-5-gliadin-ab level may serve as a marker for clinical 
      reactivity in wheat-sensitized individuals.
FAU - Ito, K
AU  - Ito K
AD  - Department of Allergy, Aichi Children's Health and Medical Center, Obu, Japan.
FAU - Futamura, M
AU  - Futamura M
FAU - Borres, M P
AU  - Borres MP
FAU - Takaoka, Y
AU  - Takaoka Y
FAU - Dahlstrom, J
AU  - Dahlstrom J
FAU - Sakamoto, T
AU  - Sakamoto T
FAU - Tanaka, A
AU  - Tanaka A
FAU - Kohno, K
AU  - Kohno K
FAU - Matsuo, H
AU  - Matsuo H
FAU - Morita, E
AU  - Morita E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (omega-5 gliadin, wheat)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-90-3 (Gliadin)
SB  - IM
MH  - Allergens/*immunology
MH  - Antigens, Plant
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gliadin/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Japan
MH  - Male
MH  - Mouth/*immunology
MH  - Triticum/*immunology
MH  - Wheat Hypersensitivity/blood/*immunology
EDAT- 2008/10/18 09:00
MHDA- 2009/07/08 09:00
CRDT- 2008/10/18 09:00
PHST- 2008/10/18 09:00 [pubmed]
PHST- 2009/07/08 09:00 [medline]
PHST- 2008/10/18 09:00 [entrez]
AID - ALL1753 [pii]
AID - 10.1111/j.1398-9995.2008.01753.x [doi]
PST - ppublish
SO  - Allergy. 2008 Nov;63(11):1536-42. doi: 10.1111/j.1398-9995.2008.01753.x.