PMID- 18926283
OWN - NLM
STAT- MEDLINE
DCOM- 20081114
LR  - 20081017
IS  - 0161-5890 (Print)
IS  - 0161-5890 (Linking)
VI  - 45
IP  - 16
DP  - 2008 Oct
TI  - Complement production and regulation by dendritic cells: molecular switches 
      between tolerance and immunity.
PG  - 4064-72
LID - 10.1016/j.molimm.2008.07.015 [doi]
AB  - In recent years it has become clear that the innate and adaptive immune systems 
      are highly integrated and interact at several levels. Dendritic cells (DCs) are 
      on the one hand instrumental for directing and controlling adaptive immunity and 
      on the other hand are specialized in detecting and integrating signals from the 
      microenvironment. In view of the strong link between deficiencies in certain 
      complement components and the development of autoimmunity, interaction between 
      complement and DCs seems to be of fundamental importance. We will discuss the 
      role of C1q, C3, as well as complement regulators in DC biology.
FAU - van Kooten, Cees
AU  - van Kooten C
AD  - Department of Nephrology, Leiden University Medical Center, Leiden, The 
      Netherlands. Kooten@lumc.nl
FAU - Fiore, Nicoletta
AU  - Fiore N
FAU - Trouw, Leendert A
AU  - Trouw LA
FAU - Csomor, Eszter
AU  - Csomor E
FAU - Xu, Wei
AU  - Xu W
FAU - Castellano, Giuseppe
AU  - Castellano G
FAU - Daha, Mohamed R
AU  - Daha MR
FAU - Gelderman, Kyra A
AU  - Gelderman KA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Complement C3)
RN  - 80295-33-6 (Complement C1q)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Animals
MH  - Complement C1q/immunology
MH  - Complement C3/immunology
MH  - Complement System Proteins/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance/*immunology
MH  - Immunity/*immunology
MH  - Macrophages/immunology
MH  - Models, Immunological
RF  - 103
EDAT- 2008/10/18 09:00
MHDA- 2008/11/15 09:00
CRDT- 2008/10/18 09:00
PHST- 2008/06/04 00:00 [received]
PHST- 2008/07/12 00:00 [accepted]
PHST- 2008/10/18 09:00 [pubmed]
PHST- 2008/11/15 09:00 [medline]
PHST- 2008/10/18 09:00 [entrez]
AID - S0161-5890(08)00292-7 [pii]
AID - 10.1016/j.molimm.2008.07.015 [doi]
PST - ppublish
SO  - Mol Immunol. 2008 Oct;45(16):4064-72. doi: 10.1016/j.molimm.2008.07.015.