PMID- 18926300
OWN - NLM
STAT- MEDLINE
DCOM- 20090205
LR  - 20201215
IS  - 0171-2985 (Print)
IS  - 0171-2985 (Linking)
VI  - 213
IP  - 9-10
DP  - 2008
TI  - GM-CSF in the generation of dendritic cells from human blood monocyte precursors: 
      recent advances.
PG  - 859-70
LID - 10.1016/j.imbio.2008.07.017 [doi]
AB  - Dendritic cells (DCs) play a key role in the orchestration of the immune system 
      by virtue of their capacity to control both immunity and tolerance induction. The 
      functions of DCs depend on the subset as well as their location and activation 
      state. A number of in vitro protocols, developed to recapitulate DC generation 
      from hematopoietic precursors, have suggested the importance of microenvironment 
      and cytokine milieu in driving the generation of DCs endowed with peculiar 
      phenotypic and functional features. Recently, some important concepts on the 
      development of DCs from human blood monocytes have been challenged. The finding 
      that human DCs can be generated from monocytes in the presence of 
      granulocyte/macrophage colony-stimulating factor (GM-CSF) alone points to this 
      cytokine as a direct player, rather than a survival-promoting factor, in the 
      development of DCs with distinct properties. This review summarizes the role of 
      different cytokine cocktails in the in vitro generation of human DCs from blood 
      monocyte precursors, focusing on GM-CSF as a direct player in the generation of 
      functionally distinct DCs.
FAU - Conti, Lucia
AU  - Conti L
AD  - Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale 
      Regina Elena 299, 00161 Rome, Italy.
FAU - Gessani, Sandra
AU  - Gessani S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080902
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Granulocyte-Macrophage Colony-Stimulating Factor)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Cell Differentiation/immunology
MH  - Cytokines/immunology/*metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/*physiology
MH  - Humans
MH  - Monocytes/*immunology/metabolism
MH  - Receptors, Granulocyte-Macrophage Colony-Stimulating 
      Factor/immunology/*metabolism
RF  - 80
EDAT- 2008/10/18 09:00
MHDA- 2009/02/06 09:00
CRDT- 2008/10/18 09:00
PHST- 2008/07/23 00:00 [received]
PHST- 2008/07/23 00:00 [accepted]
PHST- 2008/10/18 09:00 [pubmed]
PHST- 2009/02/06 09:00 [medline]
PHST- 2008/10/18 09:00 [entrez]
AID - S0171-2985(08)00088-0 [pii]
AID - 10.1016/j.imbio.2008.07.017 [doi]
PST - ppublish
SO  - Immunobiology. 2008;213(9-10):859-70. doi: 10.1016/j.imbio.2008.07.017. Epub 2008 
      Sep 2.