PMID- 18926573
OWN - NLM
STAT- MEDLINE
DCOM- 20090204
LR  - 20081117
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 161
IP  - 3
DP  - 2008 Dec 15
TI  - Reduced auditory evoked potential component N100 in schizophrenia--a critical 
      review.
PG  - 259-74
LID - 10.1016/j.psychres.2008.03.017 [doi]
AB  - The role of a reduced N100 (or N1) component of the auditory event related 
      potential as a potential trait marker of schizophrenia is critically discussed in 
      this review. We suggest that the extent of the N100 amplitude reduction in 
      schizophrenia depends on experimental and subject factors, as well as on clinical 
      variables: N100 is more consistently reduced in studies using interstimulus 
      intervals (ISIs) >1 s than in studies using shorter ISIs. An increase of the N100 
      amplitude by allocation of attention is often lacking in schizophrenia patients. 
      A reduction of the N100 amplitude is nevertheless also observed when such an 
      allocation is not required, proposing that both endogenous and exogenous 
      constituents of the N100 are affected by schizophrenia. N100 is more consistently 
      reduced in medicated than unmedicated patients, but a reduction of the N100 
      amplitude as a consequence of antipsychotic medication was shown in only two of 
      seven studies. In line with that, the association between the N100 reduction and 
      degree of psychopathology of patients appears to be weak overall. A reduced N100 
      amplitude is found in first degree relatives of schizophrenia patients, but the 
      risk of developing schizophrenia is not reflected in the N100 amplitude 
      reduction.
FAU - Rosburg, Timm
AU  - Rosburg T
AD  - Department of Epileptology, University of Bonn, Bonn, Germany. 
      timm.rosburg@ukb.uni-bonn.de
FAU - Boutros, Nash N
AU  - Boutros NN
FAU - Ford, Judith M
AU  - Ford JM
LA  - eng
GR  - R01 MH063476/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20081015
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Acoustic Stimulation
MH  - Antipsychotic Agents/therapeutic use
MH  - Attention/drug effects/physiology
MH  - Auditory Perception/drug effects/physiology
MH  - Brain Mapping
MH  - Cerebral Cortex/physiopathology
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/drug effects/genetics/*physiology
MH  - Genetic Predisposition to Disease/genetics
MH  - Humans
MH  - Nerve Net/physiopathology
MH  - Schizophrenia/diagnosis/drug therapy/genetics/*physiopathology
MH  - Signal Processing, Computer-Assisted
RF  - 130
EDAT- 2008/10/18 09:00
MHDA- 2009/02/05 09:00
CRDT- 2008/10/18 09:00
PHST- 2007/01/29 00:00 [received]
PHST- 2007/09/10 00:00 [revised]
PHST- 2008/03/14 00:00 [accepted]
PHST- 2008/10/18 09:00 [pubmed]
PHST- 2009/02/05 09:00 [medline]
PHST- 2008/10/18 09:00 [entrez]
AID - S0165-1781(08)00078-4 [pii]
AID - 10.1016/j.psychres.2008.03.017 [doi]
PST - ppublish
SO  - Psychiatry Res. 2008 Dec 15;161(3):259-74. doi: 10.1016/j.psychres.2008.03.017. 
      Epub 2008 Oct 15.