PMID- 18927281
OWN - NLM
STAT- MEDLINE
DCOM- 20081216
LR  - 20231213
IS  - 1078-0432 (Print)
IS  - 1078-0432 (Linking)
VI  - 14
IP  - 20
DP  - 2008 Oct 15
TI  - Mucosa-associated lymphoid tissue lymphoma: novel translocations including 
      rearrangements of ODZ2, JMJD2C, and CNN3.
PG  - 6426-31
LID - 10.1158/1078-0432.CCR-08-0702 [doi]
AB  - PURPOSE: The well-known translocations identified in MALT lymphomas include 
      t(11;18)/API2-MALT1, t(1;14)/IGH-BCL10, and t(14;18)/IGH-MALT1. Molecular 
      investigations have suggested that these three disparate translocations affect a 
      common pathway, resulting in the constitutive activation of nuclear 
      factor-kappaB. However, the vast majority of MALT lymphomas are negative for any 
      of the above-mentioned translocations and the underlying pathogenesis is unclear. 
      EXPERIMENTAL DESIGN: Fresh tissue of 29 gastric and extragastric MALT lymphomas 
      was studied for genetic aberrations by conventional karyotyping, long-distance 
      inverse PCR (LDI-PCR), fluorescence in situ hybridization (FISH), reverse 
      transcription-PCR (RT-PCR), and real-time quantitative RT-PCR (QRT-PCR). RESULTS: 
      Conventional cytogenetics, FISH, and RT-PCR identified aberrations in 26 of 29 
      MALT lymphoma. Balanced translocations were found in 21 cases. IGH was rearranged 
      in the majority of cases with balanced translocations (n = 17/21); 3 cases had 
      t(11;18)/API2-MALT1 and 1 case had novel t(6;7)(q25;q11), respectively. IGH 
      partner genes involved MALT1, FOXP1, BCL6, and four new chromosomal regions on 
      chromosome arms 1p, 1q, 5q, and 9p. LDI-PCR identified three novel partner genes 
      on 1p (CNN3), 5q (ODZ2), and 9p (JMJD2C). FISH assays were established and 
      confirmed LDI-PCR results. QRT-PCR showed deregulation of the novel genes in the 
      translocation-positive cases. CONCLUSIONS: Our study expands the knowledge on the 
      genetic heterogeneity of MALT lymphomas.
FAU - Vinatzer, Ursula
AU  - Vinatzer U
AD  - Department of Pathology and Internal Medicine 1, Medical University of Vienna, 
      Vienna, Austria.
FAU - Gollinger, Michaela
AU  - Gollinger M
FAU - Mullauer, Leonhard
AU  - Mullauer L
FAU - Raderer, Markus
AU  - Raderer M
FAU - Chott, Andreas
AU  - Chott A
FAU - Streubel, Berthold
AU  - Streubel B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for 
      Cancer Research
JID - 9502500
RN  - 0 (API2-MALT1 fusion protein, human)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (KDM4C protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (RNA, Neoplasm)
RN  - 0 (Tenascin)
RN  - 0 (Transcription Factors)
RN  - 0 (teneurin-1)
RN  - EC 1.14.11.- (Jumonji Domain-Containing Histone Demethylases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Calcium-Binding Proteins/*genetics/metabolism
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Female
MH  - *Gene Rearrangement
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Jumonji Domain-Containing Histone Demethylases
MH  - Karyotyping
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/metabolism
MH  - Male
MH  - Membrane Proteins/*genetics/metabolism
MH  - Microfilament Proteins/*genetics/metabolism
MH  - Middle Aged
MH  - Neoplasm Proteins/*genetics/metabolism
MH  - Nerve Tissue Proteins
MH  - Oncogene Proteins, Fusion/genetics
MH  - RNA, Neoplasm
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tenascin
MH  - Transcription Factors/*genetics/metabolism
MH  - Translocation, Genetic/*genetics
MH  - Calponins
EDAT- 2008/10/18 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/10/18 09:00
PHST- 2008/10/18 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/10/18 09:00 [entrez]
AID - 14/20/6426 [pii]
AID - 10.1158/1078-0432.CCR-08-0702 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2008 Oct 15;14(20):6426-31. doi: 10.1158/1078-0432.CCR-08-0702.