PMID- 18929147
OWN - NLM
STAT- MEDLINE
DCOM- 20081125
LR  - 20220317
IS  - 0093-7754 (Print)
IS  - 1532-8708 (Electronic)
IS  - 0093-7754 (Linking)
VI  - 35
IP  - 5
DP  - 2008 Oct
TI  - Progress in childhood cancer: 50 years of research collaboration, a report from 
      the Children's Oncology Group.
PG  - 484-93
LID - 10.1053/j.seminoncol.2008.07.008 [doi]
AB  - The Children's Oncology Group (COG) recently celebrated the milestone of 50 years 
      of pediatric clinical trials and collaborative research in oncology. Our group 
      had its origins in the four legacy pediatric clinical trials groups: the 
      Children's Cancer Group (CCG), the Pediatric Oncology Group (POG), the National 
      Wilms' Tumor Study Group (NWTS), and the Intergroup Rhabdomyosarcoma Study Group 
      (IRSG), which merged in 2000 to form the COG. Over the last 50 years, the 
      survival rates for childhood cancer have risen from 10% to almost 80%. Outcome in 
      acute lymphoblastic leukemia (ALL) has gone from a 6-month median survival to an 
      80% overall cure rate. We have modified therapies in most major diseases to 
      induce remission with the fewest long-term sequelae. Here we look back on our 
      advances but also look forward to the next 50 years, which will produce even more 
      successful treatments that will be tailored to the specific patient, translating 
      the tools of molecular genetics. Experience has clearly proven that everything we 
      know about the diagnosis and management of childhood cancer is a result of 
      research and the dramatic historical decrease in mortality from childhood cancer 
      is directly related to cooperative group clinical research.
FAU - O'Leary, Maura
AU  - O'Leary M
AD  - Children's Oncology Group: Group Chair's Office, Bethesda, MD, USA. 
      Maura.oleary@childrenshc.org
FAU - Krailo, Mark
AU  - Krailo M
FAU - Anderson, James R
AU  - Anderson JR
FAU - Reaman, Gregory H
AU  - Reaman GH
CN  - Children's Oncology Group
LA  - eng
GR  - U10 CA098543-06/CA/NCI NIH HHS/United States
GR  - U10 CA098413/CA/NCI NIH HHS/United States
GR  - CA 98543/CA/NCI NIH HHS/United States
GR  - U10 CA098543/CA/NCI NIH HHS/United States
GR  - CA98413/CA/NCI NIH HHS/United States
GR  - U10 CA098413-04/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Oncol
JT  - Seminars in oncology
JID - 0420432
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic
MH  - Cooperative Behavior
MH  - Humans
MH  - Medical Oncology/*organization & administration
MH  - Neoplasms/diagnosis/mortality/*therapy
MH  - Pediatrics/*organization & administration
MH  - Research/organization & administration
PMC - PMC2702720
MID - NIHMS73614
EDAT- 2008/10/22 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/10/01
CRDT- 2008/10/22 09:00
PHST- 2008/10/22 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/10/22 09:00 [entrez]
PHST- 2009/10/01 00:00 [pmc-release]
AID - S0093-7754(08)00170-X [pii]
AID - 10.1053/j.seminoncol.2008.07.008 [doi]
PST - ppublish
SO  - Semin Oncol. 2008 Oct;35(5):484-93. doi: 10.1053/j.seminoncol.2008.07.008.