PMID- 1892950
OWN - NLM
STAT- MEDLINE
DCOM- 19911024
LR  - 20151119
IS  - 0470-4606 (Print)
IS  - 0470-4606 (Linking)
IP  - 5
DP  - 1991
TI  - [Modification of the phospholipid composition of the cardiomyocyte sarcolemma in 
      izadrin-induced myocarditis].
PG  - 19-29
AB  - A modification of phospholipid composition in rat cardiomyocyte sarcolemma 
      occurring during isadrin myocarditis has been investigated. The fractions of 
      sphingomyelin (SphM), phosphatidylserine (PhS), phosphatidylinositol (PhI), 
      phosphatidylcholine (PhCh), phosphatidylethanolamine (PhEA) have been isolated. 
      The shifts in phospholipid composition during isadrin myocarditis expressing in 
      increase of the amount of choline-containing (PhCh + SphM) and decrease of acid 
      (PhS + PhI) phospholipids have been revealed. During the isadrin myocarditis the 
      incorporation of DL-[3-14C] serine in the fraction of total protein increases and 
      in the fraction of total lipids decreases. The maximum incorporation of the label 
      into total lipids in normal occurs faster than in case of myocarditis. The 
      dynamics of the label distribution between metabolically related PhS, PhEA and 
      PhCh indicates that PhS is the precursor of PhEA, the later being the precursor 
      of PhCh. The label redistribution between PhS, PhEA and PhCh occurs by the 
      sequence of metabolic transformations and by the direct base-exchange reactions. 
      The intensity of the latter has been estimated by the incorporation of 
      radioactive serine into phospholipids of the sarcolemma in vitro. The data 
      obtained demonstrate the inhibitory action of isadrin myocarditis.
FAU - Osadchaia, L M
AU  - Osadchaia LM
FAU - Stefanov, V E
AU  - Stefanov VE
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Modifikatsiia fosfolipidnogo sostava sarkolemmy kardiomiotsitov pri izadrinovom 
      miokardite.
PL  - Russia (Federation)
TA  - Nauchnye Doki Vyss Shkoly Biol Nauki
JT  - Nauchnye doklady vysshei shkoly. Biologicheskie nauki
JID - 0020417
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Membrane Lipids)
RN  - 0 (Phospholipids)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Animals
MH  - Carbon Radioisotopes
MH  - Catalysis/drug effects
MH  - Heart/*drug effects
MH  - Isoproterenol/*toxicity
MH  - Membrane Lipids/*metabolism
MH  - Myocarditis/*chemically induced/metabolism
MH  - Myocardium/*metabolism
MH  - Phospholipids/*metabolism
MH  - Rats
MH  - Sarcolemma/*drug effects/metabolism
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
PST - ppublish
SO  - Nauchnye Doki Vyss Shkoly Biol Nauki. 1991;(5):19-29.