PMID- 18929601
OWN - NLM
STAT- MEDLINE
DCOM- 20090224
LR  - 20131121
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 196
IP  - 2
DP  - 2009 Jan 23
TI  - The effects of partial and complete masculinization on the sexual differentiation 
      of nuclei that control lordotic behavior in the male rat.
PG  - 261-7
LID - 10.1016/j.bbr.2008.09.017 [doi]
AB  - Male rats, under certain experimental conditions, may show lordosis, the typical 
      expression of female sexual receptivity. This work studies the sexual 
      morphological pattern of facilitatory and inhibitory structures that control 
      lordosis. Three groups of males were neonatally subjected to a gradient of 
      androgen exposure (castrated plus injected oil (GxM+oil); castrated plus 
      androstenedione treated (GxM+AND); and sham operated [CM]); a group of control 
      females (CF) was also added. Lordotic response after these different hormonal and 
      neonatal surgical treatments, as well as the volume or number of neurons in 
      facilitatory (ventromedial nucleus of the hypothalamus [VMN]) and inhibitory (the 
      intermediate region of the lateral septum [LSi] and accessory olfactory bulb 
      [AOB]) nuclei involved in lordosis was studied in adults. The inhibition of 
      lordosis in the males seems to be associated to the neonatal presence of 
      testosterone and the consequent masculinization of the VMN, VMNvl, LSi and AOB. 
      It is suggested that one of the functions of the sex differences consistently 
      seen in these structures might be to inhibit the lordosis response in the male.
FAU - Segovia, Santiago
AU  - Segovia S
AD  - Departamento de Psicobiologia, UNED, Madrid, Spain.
FAU - Garcia-Falgueras, Alicia
AU  - Garcia-Falgueras A
FAU - Perez-Laso, Carmen
AU  - Perez-Laso C
FAU - Pinos, Helena
AU  - Pinos H
FAU - Carrillo, Beatriz
AU  - Carrillo B
FAU - Collado, Paloma
AU  - Collado P
FAU - Claro, Francisco
AU  - Claro F
FAU - Guillamon, Antonio
AU  - Guillamon A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080926
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 409J2J96VR (Androstenedione)
SB  - IM
MH  - Androstenedione/pharmacology
MH  - Animals
MH  - Cell Count
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Feminization
MH  - Male
MH  - Neurons/physiology
MH  - Olfactory Bulb/anatomy & histology/cytology/physiology
MH  - Orchiectomy
MH  - Rats
MH  - Septum of Brain/anatomy & histology/cytology/physiology
MH  - Sex Differentiation/*physiology
MH  - Sexual Behavior, Animal/*physiology
MH  - Ventromedial Hypothalamic Nucleus/anatomy & histology/cytology/physiology
EDAT- 2008/10/22 09:00
MHDA- 2009/02/25 09:00
CRDT- 2008/10/22 09:00
PHST- 2008/07/01 00:00 [received]
PHST- 2008/09/11 00:00 [revised]
PHST- 2008/09/16 00:00 [accepted]
PHST- 2008/10/22 09:00 [pubmed]
PHST- 2009/02/25 09:00 [medline]
PHST- 2008/10/22 09:00 [entrez]
AID - S0166-4328(08)00530-5 [pii]
AID - 10.1016/j.bbr.2008.09.017 [doi]
PST - ppublish
SO  - Behav Brain Res. 2009 Jan 23;196(2):261-7. doi: 10.1016/j.bbr.2008.09.017. Epub 
      2008 Sep 26.