PMID- 18930672
OWN - NLM
STAT- MEDLINE
DCOM- 20090406
LR  - 20161020
IS  - 1528-3933 (Electronic)
IS  - 1091-8531 (Linking)
VI  - 12
IP  - 6
DP  - 2008 Dec
TI  - Retrospective analysis of children with uveitis treated with infliximab.
PG  - 611-3
LID - 10.1016/j.jaapos.2008.08.007 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) antagonists have been successfully used 
      in refractory cases of pediatric uveitis.(1-7) We report our experience with the 
      monoclonal anti-TNF-alpha antibody infliximab in the treatment of uveitis in 20 
      children. Twenty children with noninfectious uveitis were treated with infliximab 
      as an initial line of immunomodulatory therapy (4 children) or for uncontrolled 
      intraocular inflammation despite aggressive immunosuppressive therapy (16 
      children). Intraocular inflammation was controlled in the short term in all 
      children; resistance developed in 4 children after long-term therapy.
FAU - Tugal-Tutkun, Ilknur
AU  - Tugal-Tutkun I
AD  - Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey. itutkun@istanbul.edu.tr
FAU - Ayranci, Ozen
AU  - Ayranci O
FAU - Kasapcopur, Ozgur
AU  - Kasapcopur O
FAU - Kir, Nur
AU  - Kir N
LA  - eng
PT  - Journal Article
DEP - 20081019
PL  - United States
TA  - J AAPOS
JT  - Journal of AAPOS : the official publication of the American Association for 
      Pediatric Ophthalmology and Strabismus
JID - 9710011
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - B72HH48FLU (Infliximab)
SB  - IM
MH  - Adolescent
MH  - Anti-Inflammatory Agents/administration & dosage/adverse effects/*therapeutic use
MH  - Antibodies, Monoclonal/administration & dosage/adverse effects/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Drug Administration Schedule
MH  - Drug Resistance
MH  - Female
MH  - Humans
MH  - Infliximab
MH  - Male
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
MH  - Uveitis/*drug therapy
EDAT- 2008/10/22 09:00
MHDA- 2009/04/07 09:00
CRDT- 2008/10/22 09:00
PHST- 2008/02/18 00:00 [received]
PHST- 2008/07/05 00:00 [revised]
PHST- 2008/08/13 00:00 [accepted]
PHST- 2008/10/22 09:00 [pubmed]
PHST- 2009/04/07 09:00 [medline]
PHST- 2008/10/22 09:00 [entrez]
AID - S1091-8531(08)00325-X [pii]
AID - 10.1016/j.jaapos.2008.08.007 [doi]
PST - ppublish
SO  - J AAPOS. 2008 Dec;12(6):611-3. doi: 10.1016/j.jaapos.2008.08.007. Epub 2008 Oct 
      19.