PMID- 18931100
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20220716
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 32
IP  - 1
DP  - 2009 Jan
TI  - Circulating levels of adipocyte and epidermal fatty acid-binding proteins in 
      relation to nephropathy staging and macrovascular complications in type 2 
      diabetic patients.
PG  - 132-4
LID - 10.2337/dc08-1333 [doi]
AB  - OBJECTIVE: To investigate the relationships of serum adipocyte fatty acid-binding 
      protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal 
      dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH 
      DESIGN AND METHODS: The associations of serum A-FABP and E-FABP with markers of 
      renal function, nephropathy staging, and macrovascular complications were 
      examined in 237 type 2 diabetic patients. RESULTS: Serum A-FABP and E-FABP 
      correlated significantly with serum creatinine, mean albumin excretion rate, and 
      glomerular filtration rate (all P < 0.001) and were independently associated with 
      diabetic nephropathy staging (P = 0.001 and P < 0.05, respectively). Circulating 
      levels of both types of FABP were increased (P < 0.01) in subjects with 
      macrovascular complications. Serum A-FABP was independently associated with 
      macrovascular complications (odds ratio 2.92 [95% CI 1.42-6.01]; P = 0.004). 
      CONCLUSIONS: Serum A-FABP and E-FABP might be novel serum biomarkers for 
      evaluating the progression of nephropathy and its cardiovascular risk in type 2 
      diabetic patients.
FAU - Yeung, Dennis C Y
AU  - Yeung DC
AD  - Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, 
      Hong Kong, China.
FAU - Xu, Aimin
AU  - Xu A
FAU - Tso, Annette W K
AU  - Tso AW
FAU - Chow, W S
AU  - Chow WS
FAU - Wat, Nelson M S
AU  - Wat NM
FAU - Fong, Carol H Y
AU  - Fong CH
FAU - Tam, Sidney
AU  - Tam S
FAU - Sham, Pak C
AU  - Sham PC
FAU - Lam, Karen S L
AU  - Lam KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081017
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (FABP4 protein, human)
RN  - 0 (FABP5 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Serum Albumin)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adipocytes/pathology/physiology
MH  - Adult
MH  - Aged
MH  - Albuminuria
MH  - Cohort Studies
MH  - Creatinine/blood
MH  - Diabetes Mellitus, Type 2/*blood/complications/urine
MH  - Diabetic Nephropathies/*blood/physiopathology/urine
MH  - Epidermis/pathology/physiology
MH  - Fatty Acid-Binding Proteins/*blood
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Serum Albumin/metabolism
PMC - PMC2606847
EDAT- 2008/10/22 09:00
MHDA- 2013/01/04 06:00
PMCR- 2010/01/01
CRDT- 2008/10/22 09:00
PHST- 2008/10/22 09:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
PHST- 2008/10/22 09:00 [entrez]
PHST- 2010/01/01 00:00 [pmc-release]
AID - dc08-1333 [pii]
AID - 321132 [pii]
AID - 10.2337/dc08-1333 [doi]
PST - ppublish
SO  - Diabetes Care. 2009 Jan;32(1):132-4. doi: 10.2337/dc08-1333. Epub 2008 Oct 17.