PMID- 18931483
OWN - NLM
STAT- MEDLINE
DCOM- 20081112
LR  - 20191003
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Print)
IS  - 1424-8581 (Linking)
VI  - 122
IP  - 1
DP  - 2008
TI  - A 4,103 marker integrated physical and comparative map of the horse genome.
PG  - 28-36
LID - 10.1159/000151313 [doi]
AB  - A comprehensive second-generation whole genome radiation hybrid (RH II), 
      cytogenetic and comparative map of the horse genome (2n = 64) has been developed 
      using the 5000rad horse x hamster radiation hybrid panel and fluorescence in situ 
      hybridization (FISH). The map contains 4,103 markers (3,816 RH; 1,144 FISH) 
      assigned to all 31 pairs of autosomes and the X chromosome. The RH maps of 
      individual chromosomes are anchored and oriented using 857 cytogenetic markers. 
      The overall resolution of the map is one marker per 775 kilobase pairs (kb), 
      which represents a more than five-fold improvement over the first-generation map. 
      The RH II incorporates 920 markers shared jointly with the two recently reported 
      meiotic maps. Consequently the two maps were aligned with the RH II maps of 
      individual autosomes and the X chromosome. Additionally, a comparative map of the 
      horse genome was generated by connecting 1,904 loci on the horse map with genome 
      sequences available for eight diverse vertebrates to highlight regions of 
      evolutionarily conserved syntenies, linkages, and chromosomal breakpoints. The 
      integrated map thus obtained presents the most comprehensive information on the 
      physical and comparative organization of the equine genome and will assist future 
      assemblies of whole genome BAC fingerprint maps and the genome sequence. It will 
      also serve as a tool to identify genes governing health, disease and performance 
      traits in horses and assist us in understanding the evolution of the equine 
      genome in relation to other species.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Raudsepp, T
AU  - Raudsepp T
AD  - Department of Veterinary Integrative Biosciences, Texas A&M University, College 
      Station, TX 77843, USA. traudsepp@cvm.tamu.edu
FAU - Gustafson-Seabury, A
AU  - Gustafson-Seabury A
FAU - Durkin, K
AU  - Durkin K
FAU - Wagner, M L
AU  - Wagner ML
FAU - Goh, G
AU  - Goh G
FAU - Seabury, C M
AU  - Seabury CM
FAU - Brinkmeyer-Langford, C
AU  - Brinkmeyer-Langford C
FAU - Lee, E-J
AU  - Lee EJ
FAU - Agarwala, R
AU  - Agarwala R
FAU - Stallknecht-Rice, E
AU  - Stallknecht-Rice E
FAU - Schaffer, A A
AU  - Schaffer AA
FAU - Skow, L C
AU  - Skow LC
FAU - Tozaki, T
AU  - Tozaki T
FAU - Yasue, H
AU  - Yasue H
FAU - Penedo, M C T
AU  - Penedo MC
FAU - Lyons, L A
AU  - Lyons LA
FAU - Khazanehdari, K A
AU  - Khazanehdari KA
FAU - Binns, M M
AU  - Binns MM
FAU - MacLeod, J N
AU  - MacLeod JN
FAU - Distl, O
AU  - Distl O
FAU - Guerin, G
AU  - Guerin G
FAU - Leeb, T
AU  - Leeb T
FAU - Mickelson, J R
AU  - Mickelson JR
FAU - Chowdhary, B P
AU  - Chowdhary BP
LA  - eng
GR  - Z99 LM999999/Intramural NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20081014
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Animals
MH  - Chromosome Mapping/methods/*veterinary
MH  - Chromosomes, Artificial, Bacterial/genetics
MH  - Cytogenetics
MH  - Genetic Markers
MH  - Horses/*genetics
MH  - In Situ Hybridization, Fluorescence/veterinary
MH  - Lod Score
MH  - Physical Chromosome Mapping/veterinary
MH  - Radiation Hybrid Mapping/veterinary
MH  - Species Specificity
PMC - PMC2587302
MID - NIHMS53977
EDAT- 2008/10/22 09:00
MHDA- 2008/11/13 09:00
PMCR- 2009/01/01
CRDT- 2008/10/22 09:00
PHST- 2008/06/09 00:00 [accepted]
PHST- 2008/10/22 09:00 [pubmed]
PHST- 2008/11/13 09:00 [medline]
PHST- 2008/10/22 09:00 [entrez]
PHST- 2009/01/01 00:00 [pmc-release]
AID - 000151313 [pii]
AID - 10.1159/000151313 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2008;122(1):28-36. doi: 10.1159/000151313. Epub 2008 Oct 
      14.