PMID- 1893611
OWN - NLM
STAT- MEDLINE
DCOM- 19911023
LR  - 20190918
IS  - 0730-0077 (Print)
IS  - 0730-0077 (Linking)
VI  - 13
IP  - 3
DP  - 1991
TI  - Effect of circulating factors on vascular smooth muscle contraction and its 
      calcium uptake in uremia.
PG  - 383-400
AB  - Uremia is often associated with alterations in calcium metabolism and vascular 
      smooth muscle function in hypertension and atherosclerosis. The ways in which 
      these conditions inter-relate are not clearly understood. In order to study the 
      possibility that circulating factors might influence smooth muscle function, 
      experiments were performed on rat aortic strips. The serum from both uremic 
      patients and rats enhanced the norepinephrine-induced contraction (NEIC) and net 
      45-calcium uptake in rat aortic strips. In a similar manner, the serum of 
      parathyroidectomized uremic rats also increased the NEIC, whereas verapamil 
      reduced the aortic response to levels below those of the control, in the presence 
      of uremic serum. These findings suggest that in both chronic (patients) and early 
      (rats) stages of uremia, there is a circulating factor, different from 
      parathyroid hormone, that affects calcium uptake and vascular smooth muscle 
      contraction.
FAU - Banos, G
AU  - Banos G
AD  - Department of Biochemistry, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Mexico City.
FAU - Franco, M
AU  - Franco M
FAU - Bobadilla, N A
AU  - Bobadilla NA
FAU - Lopez-Zetina, P
AU  - Lopez-Zetina P
FAU - Ceballos, G
AU  - Ceballos G
FAU - Ponce, A
AU  - Ponce A
FAU - Ramirez, D
AU  - Ramirez D
FAU - Herrera-Acosta, J
AU  - Herrera-Acosta J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Exp Hypertens A
JT  - Clinical and experimental hypertension. Part A, Theory and practice
JID - 8207790
RN  - 0 (Cardiovascular Agents)
RN  - SY7Q814VUP (Calcium)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Aorta, Thoracic/physiopathology
MH  - Biological Transport, Active
MH  - Calcium/*metabolism
MH  - Cardiovascular Agents/blood
MH  - Female
MH  - Humans
MH  - In Vitro Techniques
MH  - Male
MH  - Muscle Contraction/physiology
MH  - Muscle, Smooth, Vascular/*physiopathology
MH  - Norepinephrine/pharmacology
MH  - Parathyroidectomy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Uremia/blood/*physiopathology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.3109/10641969109045058 [doi]
PST - ppublish
SO  - Clin Exp Hypertens A. 1991;13(3):383-400. doi: 10.3109/10641969109045058.