PMID- 18939893
OWN - NLM
STAT- MEDLINE
DCOM- 20090610
LR  - 20161018
IS  - 0730-7268 (Print)
IS  - 0730-7268 (Linking)
VI  - 28
IP  - 3
DP  - 2009 Mar
TI  - Disposition of perfluorinated acid isomers in Sprague-Dawley rats; part 2: 
      subchronic dose.
PG  - 555-67
LID - 10.1897/08-254.1 [doi]
AB  - Two major industrial synthetic pathways have been used to produce perfluorinated 
      acids (PFAs) or their precursors: Telomerization and electrochemical fluorination 
      (ECF). Products of telomer and ECF origin can be distinguished by structural 
      isomer profiles. A mixture of linear and branched perfluoroalkyl isomers is 
      associated with ECF. Telomer products characteristically consist of a single 
      perfluoroalkyl geometry, typically linear. In biota, it is unclear if the isomer 
      profile is conserved relative to the exposure medium and hence whether PFA isomer 
      profiles in organisms are useful for distinguishing environmental PFA sources. A 
      companion study suggested isomer-specific disposition following a single oral 
      gavage exposure to rats. To confirm these findings under a more realistic 
      subchronic feeding scenario, male and female rats were administered PFA isomers 
      by diet for 12 weeks, followed by a 12-week depuration period. The diet contained 
      500 ng/g each of ECF perfluorooctanoate (PFOA, approximately 80% n-PFOA), ECF 
      perfluorooctane sulfonate (PFOS, approximately 70% n-PFOS), and linear and 
      isopropyl perfluorononanoate (n- and iso-PFNA). Blood sampling during the 
      exposure phase revealed preferential accumulation of n-PFOA and n-PFNA compared 
      to most branched isomers. Female rats depurated all isomers faster than males. 
      Both sexes eliminated most branched perfluorocarboxylate isomers more rapidly 
      than the n-isomer. Elimination rates of the major branched PFOS isomers were not 
      statistically different from n-PFOS. Two minor isomers of ECF PFOA and one 
      branched PFOS isomer had longer elimination half-lives than the n-isomers. 
      Although extrapolation of these pharmacokinetics trends in rats to humans and 
      wildlife requires careful consideration of dosage level and species-specific 
      physiology, cumulative evidence suggests that perfluorocarboxylate isomer 
      profiles in biota may not be suitable for quantifying the relative contributions 
      of telomer and ECF sources.
FAU - De Silva, Amila O
AU  - De Silva AO
AD  - Department of Chemistry, University of Toronto, Ontario, Canada.
FAU - Benskin, Jonathan P
AU  - Benskin JP
FAU - Martin, Leah J
AU  - Martin LJ
FAU - Arsenault, Gilles
AU  - Arsenault G
FAU - McCrindle, Robert
AU  - McCrindle R
FAU - Riddell, Nicole
AU  - Riddell N
FAU - Martin, Jonathan W
AU  - Martin JW
FAU - Mabury, Scott A
AU  - Mabury SA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081021
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Fluorinated)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Drug Administration Schedule
MH  - Environmental Pollutants/*administration & dosage/blood/*pharmacokinetics/urine
MH  - Feces/chemistry
MH  - Feeding Behavior/drug effects
MH  - Female
MH  - Hydrocarbons, Fluorinated/*administration & dosage/blood/*pharmacokinetics/urine
MH  - Isomerism
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tissue Distribution
EDAT- 2008/10/23 09:00
MHDA- 2009/06/11 09:00
CRDT- 2008/10/23 09:00
PHST- 2008/05/29 00:00 [received]
PHST- 2008/10/02 00:00 [accepted]
PHST- 2008/10/23 09:00 [pubmed]
PHST- 2009/06/11 09:00 [medline]
PHST- 2008/10/23 09:00 [entrez]
AID - 08-254 [pii]
AID - 10.1897/08-254.1 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2009 Mar;28(3):555-67. doi: 10.1897/08-254.1. Epub 2008 Oct 
      21.