PMID- 18939942
OWN - NLM
STAT- MEDLINE
DCOM- 20090303
LR  - 20221207
IS  - 1090-6576 (Print)
IS  - 1557-7473 (Electronic)
IS  - 1090-6576 (Linking)
VI  - 12
IP  - 4
DP  - 2008 Dec
TI  - Association of smoking behavior with an odorant receptor allele telomeric to the 
      human major histocompatibility complex.
PG  - 481-6
LID - 10.1089/gte.2008.0029 [doi]
AB  - Smoking behavior has been associated in two independent European cohorts with the 
      most common Caucasian human leukocyte antigen (HLA) haplotype (A1-B8-DR3). We 
      aimed to test whether polymorphic members of the two odorant receptor (OR) 
      clusters within the extended HLA complex might be responsible for the observed 
      association, by genotyping a cohort of Hungarian women in which the mentioned 
      association had been found. One hundred and eighty HLA haplotypes from Centre 
      d'Etude du Polymorphisme Humain families were analyzed in silico to identify 
      single-nucleotide polymorphisms (SNPs) within OR genes that are in linkage 
      disequilibrium with the A1-B8-DR3 haplotype, as well as with two other haplotypes 
      indirectly linked to smoking behavior. A nonsynonymous SNP within the OR12D3 gene 
      (rs3749971(T)) was found to be linked to the A1-B8-DR3 haplotype. This 
      polymorphism leads to a (97)Thr --> Ile exchange that affects a putative ligand 
      binding region of the OR12D3 protein. Smoking was found to be associated in the 
      Hungarian cohort with the rs3749971(T) allele (p = 1.05 x 10(-2)), with higher 
      significance than with A1-B8-DR3 (p = 2.38 x 10(-2)). Our results link smoking to 
      a distinct OR allele, and demonstrate that the rs3749971(T) polymorphism is 
      associated with the HLA haplotype-dependent differential recognition of cigarette 
      smoke components, at least among Caucasian women.
FAU - Santos, Pablo Sandro Carvalho
AU  - Santos PS
AD  - Institut fur Immungenetik, Charite-Universitatsmedizin Berlin , Berlin, Germany.
FAU - Fust, George
AU  - Fust G
FAU - Prohaszka, Zoltan
AU  - Prohaszka Z
FAU - Volz, Armin
AU  - Volz A
FAU - Horton, Roger
AU  - Horton R
FAU - Miretti, Marcos
AU  - Miretti M
FAU - Yu, Chack-Yung
AU  - Yu CY
FAU - Beck, Stephan
AU  - Beck S
FAU - Uchanska-Ziegler, Barbara
AU  - Uchanska-Ziegler B
FAU - Ziegler, Andreas
AU  - Ziegler A
LA  - eng
GR  - 084071/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genet Test
JT  - Genetic testing
JID - 9802546
RN  - 0 (HLA-A1 Antigen)
RN  - 0 (HLA-B8 Antigen)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (Receptors, Odorant)
SB  - IM
MH  - Alleles
MH  - Cohort Studies
MH  - Female
MH  - HLA-A1 Antigen/genetics
MH  - HLA-B8 Antigen/genetics
MH  - HLA-DR3 Antigen/genetics
MH  - Haplotypes
MH  - Humans
MH  - Hungary
MH  - Linkage Disequilibrium
MH  - *Major Histocompatibility Complex
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Odorant/*genetics
MH  - Smoking/*genetics
MH  - Telomere/genetics
MH  - White People/genetics
PMC - PMC2635552
MID - UKMS2913
OID - NLM: UKMS2913
EDAT- 2008/10/23 09:00
MHDA- 2009/03/04 09:00
PMCR- 2009/02/03
CRDT- 2008/10/23 09:00
PHST- 2008/10/23 09:00 [entrez]
PHST- 2008/10/23 09:00 [pubmed]
PHST- 2009/03/04 09:00 [medline]
PHST- 2009/02/03 00:00 [pmc-release]
AID - 10.1089/gte.2008.0029 [doi]
PST - ppublish
SO  - Genet Test. 2008 Dec;12(4):481-6. doi: 10.1089/gte.2008.0029.