PMID- 18945496
OWN - NLM
STAT- MEDLINE
DCOM- 20090319
LR  - 20151119
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 205
IP  - 1-2
DP  - 2008 Dec 15
TI  - CSF neurofilament and soluble TNF receptor 1 levels in subacute sclerosing 
      panencephalitis.
PG  - 155-9
LID - 10.1016/j.jneuroim.2008.09.011 [doi]
AB  - Neurofilament (NF) is one of the major cytoskeleton proteins of neurons and 
      sTNFR1 is thought to reflect the true biological activity of TNF-alpha. To 
      evaluate the levels of the heavy subunit of neurofilament (NF-H) and soluble TNF 
      receptor 1 (sTNFR1) in cerebrospinal fluid (CSF) as biomarkers of clinical 
      severity of subacute sclerosing panencephalitis (SSPE), concentrations of NF-H 
      and sTNFR1 in CSF of 34 patients with SSPE and in control subjects were measured 
      by ELISA. The CSF NF-H levels were significantly higher in patients with SSPE 
      than in controls (p<0.0001), and those in patients in Jabbour stage III were 
      significantly higher than in patients in stage II (p=0.015). The CSF sTNFR1 
      levels in SSPE patients were significantly higher than those in controls 
      (p=0.004), but there were no significant differences in CSF sTNFR1 levels between 
      patients in Jabbour stages II and III. There was a significant correlation 
      between CSF NF-H and sTNFR1 levels in patients with SSPE (p=0.011). We suggest 
      that CSF NF-H levels can be used as a marker of development of neuronal 
      degeneration in SSPE, and that TNF-alpha modifies the neurodestructive 
      pathogenesis in SSPE.
FAU - Matsushige, Takeshi
AU  - Matsushige T
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 
      Yamaguchi, Japan.
FAU - Ichiyama, Takashi
AU  - Ichiyama T
FAU - Anlar, Banu
AU  - Anlar B
FAU - Tohyama, Jun
AU  - Tohyama J
FAU - Nomura, Keiko
AU  - Nomura K
FAU - Yamashita, Yushiro
AU  - Yamashita Y
FAU - Furukawa, Susumu
AU  - Furukawa S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081022
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Neurofilament Proteins)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 108688-71-7 (neurofilament protein H)
RN  - OP401G7OJC (Etanercept)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/cerebrospinal fluid
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Etanercept
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/*cerebrospinal fluid
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Neurofilament Proteins/*cerebrospinal fluid
MH  - Receptors, Tumor Necrosis Factor
MH  - Statistics, Nonparametric
MH  - Subacute Sclerosing Panencephalitis/*cerebrospinal fluid/pathology
MH  - Young Adult
EDAT- 2008/10/24 09:00
MHDA- 2009/03/20 09:00
CRDT- 2008/10/24 09:00
PHST- 2008/06/20 00:00 [received]
PHST- 2008/09/16 00:00 [revised]
PHST- 2008/09/16 00:00 [accepted]
PHST- 2008/10/24 09:00 [pubmed]
PHST- 2009/03/20 09:00 [medline]
PHST- 2008/10/24 09:00 [entrez]
AID - S0165-5728(08)00415-3 [pii]
AID - 10.1016/j.jneuroim.2008.09.011 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2008 Dec 15;205(1-2):155-9. doi: 10.1016/j.jneuroim.2008.09.011. 
      Epub 2008 Oct 22.