PMID- 18946168
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20081023
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 44
IP  - 3
DP  - 2008
TI  - Maternal blood levels of persistent organic pollutants can be used to estimate in 
      utero exposure.
PG  - 281-91
AB  - The presence of persistent organic pollutants (POPs) in the fetal environment 
      raises concerns for their possible interferences with the developmental process, 
      resulting into morphological and/or functional impairments of the organism. Human 
      biomonitoring has been widely recognized as the action to be undertaken to 
      characterize children's exposure to environmental pollutants in the different 
      life stages, starting from conception. The main objective of the present study 
      was to analyze the relationship between concentrations assessed in maternal blood 
      versus those present in umbilical cord blood to evaluate if POP levels determined 
      in maternal blood can be considered representative of fetal exposure. Data on POP 
      concentrations determined in maternal blood and umbilical cord blood were 
      retrieved from literature. Studies selected used highly specific analytical 
      techniques, and were published within the last 15 years. Our analysis involved 
      POPs of high toxicological significance, as organochlorinated pesticides, 
      polychlorodibenzodioxins and poliychlorodibenzofurans, polychlorobiphenyls and 
      their hydroxylated metabolites, and polybromodiphenylethers. Linear correlations 
      between maternal and cord blood concentrations, expressed on a lipid base, were 
      observed for most of these pollutants. This result indicates a possible use of 
      data on maternal blood POP levels to quantitatively predict in utero exposure.
FAU - Abballe, Annalisa
AU  - Abballe A
AD  - Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di 
      Sanita, Rome, Italy. defelip@iss.it
FAU - Guarino, Maria
AU  - Guarino M
FAU - Taggi, Franco
AU  - Taggi F
FAU - Traina, Maria Elsa
AU  - Traina ME
FAU - Urbani, Elisabetta
AU  - Urbani E
FAU - Valentini, Silvia
AU  - Valentini S
FAU - De Felip, Elena
AU  - De Felip E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Pregnancy/*blood
MH  - Umbilical Cord/*chemistry
RF  - 38
EDAT- 2008/10/24 09:00
MHDA- 2009/01/28 09:00
CRDT- 2008/10/24 09:00
PHST- 2008/10/24 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
PHST- 2008/10/24 09:00 [entrez]
PST - ppublish
SO  - Ann Ist Super Sanita. 2008;44(3):281-91.