PMID- 18947010
OWN - NLM
STAT- MEDLINE
DCOM- 20081113
LR  - 20160518
IS  - 1875-9572 (Print)
IS  - 1875-9572 (Linking)
VI  - 49
IP  - 2
DP  - 2008 Apr
TI  - Relationship between perinatal and neonatal indices and intelligence quotient in 
      very low birth weight infants at the age of 6 or 8 years.
PG  - 13-8
LID - 10.1016/S1875-9572(08)60005-4 [doi]
AB  - BACKGROUND: The majority of children born with very low birth weight (VLBW; < 
      1500g) enter mainstream schools. They experience significant neurodevelopmental 
      disabilities during childhood. The specific aims of our study were to evaluate 
      the neonatal outcomes of VLBW infants and whether they would influence 
      intelligence quotient (IQ), cognitive function and learning disabilities at the 
      age of 6 or 8 years. METHODS: We enrolled VLBW neonates who weighed less than 
      1500g and who were delivered at Shin-Kong Wu Ho-Su Memorial Hospital in 1996 and 
      1999. The psychological assessments were applied with the Wechsler Preschool and 
      Primary Scale of Intelligence (WPPSI) for age 6 and Wechsler Intelligence Scale 
      for Children-Third Edition (WISC-III) for age 8. We recorded their demographic 
      data, ventilation duration by days, length of stay, use of surfactant, 
      respiratory distress syndrome (RDS), and other complications. RESULTS: According 
      to whether the full scale intelligence quotient (FSIQ) was above or below the 
      average score (FSIQ = 90), we divided VLBW children into two groups (< 90, n = 
      17; > or = 90, n = 21). The children with lower gestational age had lower FSIQ (p 
      = 0.013). The higher FSIQ group (> or = 90) showed more prenatal steroid use 
      (5/17, 29.4% vs. 14/21, 66.7%; p = 0.049). There were more boys in the lower FSIQ 
      group (< 90, 13/17, 76.5% vs. > or = 90, 7/21, 33.3%; p = 0.011). The average IQ 
      scores were 78.11 +/- 9.05 and 102.57 +/- 8.89 in the FSIQ < 90 and FSIQ > or = 
      90 groups, respectively. The groups were similar in ventilation duration by days, 
      use of surfactant, frequency of sepsis, RDS, bronchopulmonary dysplasia, patent 
      ductus arteriosus, intraventricular hemorrhage and retinopathy of prematurity. 
      CONCLUSION: In our study, the children with lower gestational age had lower FSIQ. 
      There was no significant association between small for gestational age and IQ 
      performance. The neonatal outcomes of VLBW infants did have less impact on IQ 
      performance later in life.
FAU - Mu, Shu-Chi
AU  - Mu SC
AD  - Department of Pediatrics, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
FAU - Lin, Cheng-Hui
AU  - Lin CH
FAU - Chen, Yi-Ling
AU  - Chen YL
FAU - Chang, Chia-Han
AU  - Chang CH
FAU - Tsou, Kuo-Inn
AU  - Tsou KI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Pediatr Neonatol
JT  - Pediatrics and neonatology
JID - 101484755
SB  - IM
MH  - Child
MH  - Cognition
MH  - Cohort Studies
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - *Infant, Very Low Birth Weight
MH  - *Intelligence
MH  - Male
EDAT- 2008/10/25 09:00
MHDA- 2008/11/14 09:00
CRDT- 2008/10/25 09:00
PHST- 2008/10/25 09:00 [pubmed]
PHST- 2008/11/14 09:00 [medline]
PHST- 2008/10/25 09:00 [entrez]
AID - S1875-9572(08)60005-4 [pii]
AID - 10.1016/S1875-9572(08)60005-4 [doi]
PST - ppublish
SO  - Pediatr Neonatol. 2008 Apr;49(2):13-8. doi: 10.1016/S1875-9572(08)60005-4.