PMID- 18948171
OWN - NLM
STAT- MEDLINE
DCOM- 20090416
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 448
IP  - 1
DP  - 2008 Dec 19
TI  - Ramp rate of blood pressure changes does not affect aortic afferent sensitivity 
      in anesthetized rats.
PG  - 37-40
LID - 10.1016/j.neulet.2008.10.037 [doi]
AB  - To investigate whether the rate of change in blood pressure affects the 
      sensitivity of the aortic baroreceptor afferent response, the change in aortic 
      nerve activity (ANA) to two different rates of ramp increase in mean blood 
      pressure (MBP), elicited by phenylephrine administration, was determined in the 
      rat under urethane (1.5 g kg(-1)) anesthesia. The sensitivity of the increase in 
      ANA following a rapid (average ramp rate, 9.14+/-0.60 mm Hg s(-1), n=11) or 
      gradual (1.78+/-0.24 mm Hg s(-1), n=11) increase in MBP was 2.03+/-0.14% and 
      1.81+/-0.20% of baseline mm Hg(-1), respectively. These values were not 
      significantly different from each other (P=0.16). Furthermore, we found no 
      correlation between the rate of ramp increase in MBP and the sensitivity of the 
      increase in ANA (r=0.24, P=0.29, n=22). These results suggest that, at least 
      within the normal physiological range of MBP, the rate of the ramp change in 
      blood pressure does not affect aortic baroreceptor afferent sensitivity in the 
      anesthetized rat.
FAU - Waki, Hidefumi
AU  - Waki H
AD  - Department of Physiology-II, Wakayama Medical University School of Medicine, 
      811-1, Kimiidera, Wakayama City 641-8509, Japan. h-waki@wakayama-med.ac.jp
FAU - Shimizu, Tsuyoshi
AU  - Shimizu T
FAU - Yamasaki, Masao
AU  - Yamasaki M
FAU - Katahira, Kiyoaki
AU  - Katahira K
FAU - Katsuda, Shinichiro
AU  - Katsuda S
FAU - Polson, Jaimie W
AU  - Polson JW
FAU - Maeda, Masanobu
AU  - Maeda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081017
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 0 (Anesthetics, Intravenous)
RN  - 1WS297W6MV (Phenylephrine)
RN  - 3IN71E75Z5 (Urethane)
SB  - IM
MH  - Adrenergic alpha-Agonists/pharmacology
MH  - Afferent Pathways/drug effects/*physiology
MH  - Anesthetics, Intravenous/*pharmacology
MH  - Animals
MH  - Aorta/*innervation
MH  - Blood Pressure/*drug effects
MH  - Male
MH  - Phenylephrine/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Urethane/*pharmacology
EDAT- 2008/10/25 09:00
MHDA- 2009/04/17 09:00
CRDT- 2008/10/25 09:00
PHST- 2008/08/19 00:00 [received]
PHST- 2008/10/09 00:00 [revised]
PHST- 2008/10/13 00:00 [accepted]
PHST- 2008/10/25 09:00 [pubmed]
PHST- 2009/04/17 09:00 [medline]
PHST- 2008/10/25 09:00 [entrez]
AID - S0304-3940(08)01432-8 [pii]
AID - 10.1016/j.neulet.2008.10.037 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Dec 19;448(1):37-40. doi: 10.1016/j.neulet.2008.10.037. Epub 
      2008 Oct 17.