PMID- 18949449
OWN - NLM
STAT- MEDLINE
DCOM- 20090414
LR  - 20221207
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 88
IP  - 5
DP  - 2008 Dec
TI  - BCL10 nuclear expression and t(11;18)(q21;q21) indicate nonresponsiveness to 
      Helicobacter pylori eradication of Chinese primary gastric MALT lymphoma.
PG  - 516-523
LID - 10.1007/s12185-008-0187-z [doi]
AB  - The eradication of Helicobacter pylori (H. pylori) with antibiotics induces 
      complete remission in 75% of patients with gastric MALT lymphoma. We investigated 
      the efficacy of H. pylori eradication and assessed the predictive value of BCL10 
      nuclear expression and t(11;18)(q21;q21) regarding resistance to H. pylori 
      eradication in primary gastric mucosa-associated lymphoid tissue lymphoma (MALT 
      lymphoma) patients from mainland China. Twenty-two gastric MALT cases (Stage 
      I(E)) underwent H. pylori eradication with antibiotics, and sequential 
      endoscopic-bioptic follow-ups were performed and assessed with regular 
      morphologic and immunohistochemical examinations. BCL10 nuclear expression and 
      interphase fluorescence in situ hybridization (FISH) for MALT1 and API2/MALT1 
      were tested. Thirteen out of the 22 cases (59.1%) achieved complete regression 
      (CR) after the eradication of H. pylori. The longest follow-up period in the 22 
      patients was 68 months, with 12 patients longer than 24 months. For the 13 CR 
      patients, the longest follow-up period after H. pylori eradication was 53 months, 
      with 6 patients longer than 24 months. BCL10 nuclear expression was detected by 
      immunohistochemical staining in 9 cases, including 7 (77.8%) of 9 cases who 
      showed no response (NR) and 2 (15.4%) of 13 patients who achieved CR following 
      eradication therapy (P < 0.05). t(11;18)(q21;q21) was evaluated by interphase 
      FISH in 18 cases including 11 CR and 7 NR patients after H. pylori eradication. 
      t(11;18)(q21;q21) was found in 4 (57.1%) of 7 patients who showed NR following H. 
      pylori eradication, but one in 11 CR patients (P < 0.05). A total of 59.1% of 
      patients with early gastric MALT lymphoma recruited in this study achieved CR 
      after H. pylori eradication. BCL10 nuclear expression and 
      t(11;18)(q21;q21)-positive gastric MALT lymphomas are likely to be related to a 
      failure to respond to H. pylori eradication in Chinese patients.
FAU - Dong, Gehong
AU  - Dong G
AD  - Department of Pathology, Peking University Health Science Center, 100191, 
      Beijing, People's Republic of China.
FAU - Liu, Cuiling
AU  - Liu C
AD  - Department of Pathology, Peking University Health Science Center, 100191, 
      Beijing, People's Republic of China.
FAU - Ye, Hongtao
AU  - Ye H
AD  - Division of Molecular Histopathology, Department of Pathology, University of 
      Cambridge, Cambridge, UK.
AD  - Department of Pathology, Guilin Medical College, 541004, Guilin, People's 
      Republic of China.
FAU - Gong, Liping
AU  - Gong L
AD  - Department of Pathology, Capital Medical University, 100069, Beijing, People's 
      Republic of China.
FAU - Zheng, Jie
AU  - Zheng J
AD  - Department of Pathology, Peking University Health Science Center, 100191, 
      Beijing, People's Republic of China.
FAU - Li, Min
AU  - Li M
AD  - Department of Pathology, Peking University Health Science Center, 100191, 
      Beijing, People's Republic of China.
FAU - Huang, Xin
AU  - Huang X
AD  - Department of Pathology, Peking University Health Science Center, 100191, 
      Beijing, People's Republic of China.
FAU - Huang, Xuebiao
AU  - Huang X
AD  - Department of Digestive Disease, Peking University Third Hospital, 100191, 
      Beijing, People's Republic of China.
FAU - Huang, Yuanjie
AU  - Huang Y
AD  - Department of Pathology, Peking University Health Science Center, 100191, 
      Beijing, People's Republic of China.
FAU - Shi, Yunfei
AU  - Shi Y
AD  - Department of Pathology, Peking University Health Science Center, 100191, 
      Beijing, People's Republic of China.
FAU - Yin, Wenjuan
AU  - Yin W
AD  - Department of Pathology, Peking University Health Science Center, 100191, 
      Beijing, People's Republic of China.
FAU - Gao, Zifen
AU  - Gao Z
AD  - Department of Pathology, Peking University Health Science Center, 100191, 
      Beijing, People's Republic of China. wjshgao@bjmu.edu.cn.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081024
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (B-Cell CLL-Lymphoma 10 Protein)
RN  - 0 (BCL10 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*biosynthesis/genetics
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-Bacterial Agents/administration & dosage
MH  - Asian People
MH  - B-Cell CLL-Lymphoma 10 Protein
MH  - China
MH  - Chromosomes, Human, Pair 11/genetics/metabolism
MH  - Chromosomes, Human, Pair 18/genetics/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene Expression Regulation, Neoplastic/drug effects
MH  - Helicobacter Infections/drug therapy/genetics/*metabolism/mortality/pathology
MH  - *Helicobacter pylori
MH  - Humans
MH  - Lymphoma, B-Cell, Marginal Zone/drug 
      therapy/genetics/*metabolism/microbiology/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Stomach Neoplasms/drug 
      therapy/genetics/*metabolism/microbiology/mortality/pathology
MH  - Translocation, Genetic
EDAT- 2008/10/25 09:00
MHDA- 2009/04/15 09:00
CRDT- 2008/10/25 09:00
PHST- 2008/02/02 00:00 [received]
PHST- 2008/09/19 00:00 [accepted]
PHST- 2008/09/18 00:00 [revised]
PHST- 2008/10/25 09:00 [pubmed]
PHST- 2009/04/15 09:00 [medline]
PHST- 2008/10/25 09:00 [entrez]
AID - 10.1007/s12185-008-0187-z [pii]
AID - 10.1007/s12185-008-0187-z [doi]
PST - ppublish
SO  - Int J Hematol. 2008 Dec;88(5):516-523. doi: 10.1007/s12185-008-0187-z. Epub 2008 
      Oct 24.