PMID- 18950294
OWN - NLM
STAT- MEDLINE
DCOM- 20090123
LR  - 20081027
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 31
IP  - 11
DP  - 2008 Nov
TI  - Nonischemic dilated cardiomyopathy: results of noninvasive and invasive 
      evaluation in 310 patients and clinical significance of bundle branch block.
PG  - 1383-90
LID - 10.1111/j.1540-8159.2008.01199.x [doi]
AB  - BACKGROUND: The survival of patients with idiopathic dilated cardiomyopathy 
      (IDCM) at III and IV stages of New York Heart Association (NYHA) is decreased in 
      those with a bundle branch block (BBB) compared to those without BBB. Less is 
      known on the prognosis of patients at earlier stages of NYHA and who had a left 
      BBB (LBBB) or right BBB (RBBB). We sought to evaluate the prevalence and the 
      clinical significance of LBBB or RBBB in patients with IDCM and classes I and II 
      of NYHA. METHODS: Clinical data, noninvasive, and invasive studies were 
      consecutively collected in 310 patients, with IDCM, followed up to 4.8+/-3.7 
      years. RESULTS: Seventy-six patients (25%) had LBBB, 21 (7%) had RBBB, and 212 
      had no BBB. Patients with BBB were older than other patients (P < 0.009). Left 
      ventricular ejection fraction (LVEF) was lower in LBBB than in RBBB and other 
      patients (P < 0.05). Syncope was more frequent in BBB than in absence (P < 0.05). 
      Incidence of spontaneous ventricular tachycardia (VT) and atrial fibrillation, VT 
      induction, total cardiac events, and sudden death were similar in the presence or 
      absence of BBB. Deaths by heart failure and heart transplantations tended to be 
      more frequent in BBB than in absence. CONCLUSIONS: LBBB was present in 25% of 
      patients with IDCM; RBBB was rare. Patients with BBB were older and had more 
      frequent syncope than patients without BBB; LVEF was lower in LBBB than in RBBB 
      or in absence of BBB. BBB did not increase the risk of spontaneous VT, VT 
      induction, or sudden death, and tended to increase deaths by heart failure and 
      the indications of heart transplantation.
FAU - Brembilla-Perrot, Beatrice
AU  - Brembilla-Perrot B
AD  - Cardiology, CHU of Brabois, Vandoeuvre Les Nancy, France. 
      b.brembilla-perrot@chu-nancy.fr
FAU - Alla, Francois
AU  - Alla F
FAU - Suty-Selton, Christine
AU  - Suty-Selton C
FAU - Huttin, Olivier
AU  - Huttin O
FAU - Blangy, Hugues
AU  - Blangy H
FAU - Sadoul, Nicolas
AU  - Sadoul N
FAU - Chometon, Frederic
AU  - Chometon F
FAU - Groben, Laurent
AU  - Groben L
FAU - Luporsi, Jean D
AU  - Luporsi JD
FAU - Zannad, Noura
AU  - Zannad N
FAU - Aliot, Etienne
AU  - Aliot E
FAU - Cedano, Juanico
AU  - Cedano J
FAU - Ammar, Sonia
AU  - Ammar S
FAU - Abdelaal, Ahmed
AU  - Abdelaal A
FAU - Juilliere, Yves
AU  - Juilliere Y
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Bundle-Branch Block/*mortality/*surgery
MH  - Cardiomyopathy, Dilated/*mortality/*surgery
MH  - Comorbidity
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/mortality/surgery
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Survival Analysis
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2008/10/28 09:00
MHDA- 2009/01/24 09:00
CRDT- 2008/10/28 09:00
PHST- 2008/10/28 09:00 [pubmed]
PHST- 2009/01/24 09:00 [medline]
PHST- 2008/10/28 09:00 [entrez]
AID - PACE1199 [pii]
AID - 10.1111/j.1540-8159.2008.01199.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2008 Nov;31(11):1383-90. doi: 
      10.1111/j.1540-8159.2008.01199.x.